Craving nicotine: It's in the genes
- Probe plugs pore. Piggot, Matthew // Chemistry in Australia;Dec2010, Vol. 78 Issue 11, p11
The article discusses a study by researchers from the universities in Australia, England and Switzerland that identified the binding site of a novel non-competitive antagonist of neuronal nicotinic receptors.
- nAChR. // Encyclopedic Reference of Molecular Pharmacology;2004, p623
An encyclopedia entry for "Nicotinic Acetylcholine Receptor (nAChR)," is presented.
- Use of knock-out mice to determine the molecular basis for the actions of nicotine. Picciotto, Marina R.; Zoli, Michele; Changeux, Jean-Pierre // Nicotine & Tobacco Research;Sep1999 Supplement, Vol. 1, pS121
Recombinant DNA techniques have been used to identify the family of molecules that mediate nicotine's effects on the brain. Nicotine binds and activates nicotinic acetylcholine receptors (nAChRs) which are made up of combinations of individual nicotinic subunits. It is important to determine...
- Genetic and functional analysis of single nucleotide polymorphisms in the Î²2-neuronal nicotinic acetylcholine receptor gene (CHRNB2). Lueders, Kira K.; Hu, Stella; McHugh, Louise; Myakishev, Max V.; Sirota, Leo A.; Hamer, Dean H. // Nicotine & Tobacco Research;Feb2002, Vol. 4 Issue 1, p115
The Î²2-neuronal nicotinic acetylcholine receptor gene (CHRNB2) is a logical candidate for influencing smoking behavior and nicotine dependence. We discovered six single nucleotide polymorphisms (SNPs) in the CHRNB2 gene by surveying 15.4 kb of genomic sequence including a previously...
- Evidence of Association between Smoking and Î±7 Nicotinic Receptor Subunit Gene in Schizophrenia Patients. De Luca, Vincenzo; Wong, Albert H.C.; Muller, Daniel J.; Wong, Gregory W.H.; Tyndale, Rachel F.; Kennedy, James L. // Neuropsychopharmacology;Aug2004, Vol. 29 Issue 8, p1522
A number of studies have suggested that the Î±-7-nicotinic receptor D15D1360 polymorphism is associated with schizophrenia and a deficiency in the normal inhibition of the P50 auditory-evoked response. Schizophrenia patients and some of their unaffected relatives show a failure of inhibition...
- Genetic interaction between Î±4 and Î²2 subunits of high affinity nicotinic receptor: analysis in schizophrenia. de Luca, Vincenzo; Voineskos, Sophocles; Wong, Greg; Kennedy, James L. // Experimental Brain Research;Sep2006, Vol. 174 Issue 2, p292
Cholinergic dysfunction is one of the hypotheses for the cognitive deficits of schizophrenia. Neurocognitive deficits, which are well-described clinical features of schizophrenia, may be remediated by nicotine; therefore investigations of nicotinic receptor subtypes is of considerable clinical...
- Effects of subunit selective nACh receptors on operant ethanol self-administration and relapse-like ethanol-drinking behavior. Kuzmin, Alexander; Jerlhag, Elisabet; Liljequist, Sture; Engel, Jörgen // Psychopharmacology;Mar2009, Vol. 203 Issue 1, p99
The sensitivity to ethanol central effects is partially determined by the subunit composition of brain nicotinic acetylcholine receptors (nAChRs). Thus, the effects of intraventral tegmental area (VTA) administration of the nicotinic subunit-specific antagonist, Î±-conotoxin MII (Î±CtxMII,...
- Nicotine exposure and bronchial epithelial cell nicotinic acetylcholine receptor expression in the pathogenesis of lung cancer. Minna, John D. // Journal of Clinical Investigation;1/1/2003, Vol. 111 Issue 1, p31
Comments on a research on the role of neuronal nicotinic acetylcholine receptors (nAchRs) in lung cancer. Mechanism by which nicotine could block apoptosis; Cellular targets and the role of other nAchR subunit types; Biochemical events generated after nicotine interacts with its receptor.
- Î±7 Nicotinic Receptor Agonists as Potential Therapeutic Drugs for Schizophrenia. Hashimoto, Kenji; Koike, Kaori; Shimizu, Eiji; Iyo, Masaomi // Current Medicinal Chemistry - Central Nervous System Agents;Sep2005, Vol. 5 Issue 3, p171
Deficient inhibitory processing of the P50 auditory evoked potential is a measurable marker observed in schizophrenia. Several lines of evidence suggest that Î±7 nicotinic receptors (Î±7 nAChRs) play a critical role in P50 auditory sensory gating in the human brain. Similar to schizophrenic...