TITLE

Recent Progress in Structure Activity Relationship and Mechanistic Studies of Taxol Analogues

AUTHOR(S)
Fang, W.- S.; Liang, X.- T.
PUB. DATE
January 2005
SOURCE
Mini Reviews in Medicinal Chemistry;Jan2005, Vol. 5 Issue 1, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Structure activity relationship (SAR) and mechanism of paclitaxel and its analogues in recent years are discussed in the following areas: SAR of paclitaxel analogues toward “normal” and multi-drug resistance tumors; paclitaxel prodrugs with improved water solubitily and specificity; mechanism of paclitaxel related to tubulin binding and quest for its pharmacophore.
ACCESSION #
15594347

Tags: PACLITAXEL;  ANTINEOPLASTIC agents;  DRUGS -- Structure-activity relationships;  PRODRUGS;  DRUG resistance;  PHARMACEUTICAL chemistry

 

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