TITLE

Admission Serum Albumin Is Predicitve of Outcome in Critically III Trauma Patients

AUTHOR(S)
Jin Sung; Bochicchio, Grant V.; Joshi, Manjari; Bochicchio, Kelly; Costas, Ainhoa; Tracy, Kate; Scalea, Thomas M.
PUB. DATE
December 2004
SOURCE
American Surgeon;Dec2004, Vol. 70 Issue 12, p1099
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
There is a paucity of data evaluating serum albumin on admission as a predictor of outcome in adult trauma patients. Our objectives were to evaluate whether or not hypoalbuminemia on admission is a predictor of adverse outcome in trauma patients. Prospective data was collected daily on 1023 patients over a 2-year period. Patients were stratified by serum albumin level on admission, age, gender, injury severity, and comorbid conditions. Outcome was measured by ICU and hospital length of stay, ventilator days, incidence of infection, and mortality. Student t test, X2, and multilinear regression analysis were used to determine level of significance. Blunt injuries accounted for the majority (78%) of the admissions. The mean age of the study population was 43 ± 21 years with a mean Injury Severity Score (ISS) of 21.4 ± 12. The majority of patients were male (74.5%). The mean albumin level on admission was 2.9 ± 1.8. Five hundred ninety-three (58%) patients were admitted with a serum albumin level of < 2.6 as compared to 430 patients (42%) with an admission albumin level of < 2.6. Patients with a lower serum albumin level were found to have a significantly greater ICU (17.1 vs 14.2 days) and hospital length of stay (17.3 vs 20.1 days, P > 0.05), ventilator days (11.1 vs 13.5 days, P > 0.05), and mortality (P = 0.008) when matched for age and injury severity. The relative risk of infection and mortality increased greater than 2.5-fold in patients with increased age and low serum albumin when analyzed by multilinear regression analysis, P > 0.001. An admission serum albumin level of >2.6 g/dL is a significant independent predictor of morbidity and mortality in trauma patients. The combination of increased age and low albumin level was most predictive of infection and mortality. Early nutrition should be considered in these high-risk patients.
ACCESSION #
15502152

 

Related Articles

  • Serum prealbumin (transthyretin) predict good outcome in young patients with cerebral infarction. Gao, Cong; Zhang, Bin; Zhang, WeiZhi; Pu, ShuXiang; Yin, JianRui; Gao, QingChun // Clinical & Experimental Medicine;Mar2011, Vol. 11 Issue 1, p49 

    Low serum protein and albumin are considered to significantly associate with malnutrition, impaired functional status, poor outcome, and mortality. We hypothesized that serum prealbumin (transthyretin, PA) was a reliable and robust survival marker in young cerebral infarction patients and...

  • Hand grip - a simple test for morbidity after fracture of the neck of femur. Davies, C. W. Twiston; Jones, D. Moody; Shearer, J. R. // Journal of the Royal Society of Medicine;Oct1984, Vol. 77 Issue 10, p833 

    Seventy-six female patients, having sustained a fracture of the neck of femur, were assessed preoperatively by measuring their muscle strength in the form of grip using a hand-held dynamometer and by measuring serum albumin. A grip strength of < 15 kg was found to be a reliable predictor of...

  • HSA.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1096 

    An encyclopedia entry for the medical acronym "HSA," which stands for human serum albumin, is presented.

  • Intravenous iron administration induces oxidation of serum albumin in hemodialysis patients. Anraku, Maoto; Kitamura, Kenichiro; Shinohara, Ayumi; Adachi, Masataka; Suenaga, Ayaka; Maruyama, Toru; Miyanaka, Kei; Miyoshi, Taku; Shiraishi, Naoki; Nonoguchi, Hiroshi; Otagiri, Masaki; Tomita, Kimio // Kidney International;Aug2004, Vol. 66 Issue 2, p841 

    Intravenous iron administration induces oxidation of serum albumin in hemodialysis patients. Background. Intravenous iron administration (IVIR) is effective for correcting anemia in hemodialysis (HD) patients. However, it may also enhance the generation of hydroxyl radicals. Recently, plasma...

  • Inflammation, dyslipidemia and vascular risk factors in hemodialysis patients. Wanner, Christoph; Zimmerman, Josef; Quaschning, Thomas; Galle, Jan // Kidney International Supplement;Nov1997, Issue 62, pS-53 

    Cardiovascular complications account for more than 50% of death in hemodialysis patients. Strong and independent predictors of mortality or cardiovascular complications are low levels of serum albumin, high plasma C-reactive protein and lipoprotein(a), plasma proteins that are described to...

  • A phase II trial of methotrexate-human serum albumin (MTX-HSA) in patients with metastatic renal cell carcinoma who progressed under immunotherapy. Vis, A. N.; van der Gaast, A.; van Rhijn, B. W. G.; Catsburg, T. K.; Schmidt, C.; Mickisch, G. H. J. // Cancer Chemotherapy & Pharmacology;Apr2002, Vol. 49 Issue 4, p342 

    Introduction: Renal cell carcinoma (RCC) has a poor prognosis when metastasized to distant sites, although immunotherapy may offer a prolongation of survival in selected patient groups. Unfortunately, no treatment options remain when immunotherapy fails. In this phase IIa trial the tolerability...

  • Relationship between Plasma Endocan Level and Clinical Outcome of Chinese Peritoneal Dialysis Patients. Poon, Peter Yam-Kau; Ng, Jack Kit-Chung; Fung, Winston Wing-Shing; Chow, Kai-Ming; Kwan, Bonnie Ching-Ha; Li, Philip Kam-Tao; Szeto, Cheuk-Chun // Kidney & Blood Pressure Research;2019, Vol. 44 Issue 5, p1259 

    Background: Endocan is associated with endothelial dysfunction. In peritoneal dialysis (PD) patients, cardiovascular disease is a common cause of mortality. We examined the relationship between serum endocan level and clinical outcome of PD patients. Methods: We recruited 193 new PD patients...

  • Effects of Momordica charantia on Serum Lipid Profile, Serum Protein Levels and Selected Markers of Cardiovascular Damage in Diabetic Rats. Komolafe, Omobola A.; Ofusori, David A.; Adewole, Olarinde S.; Fakunle, Julius B. // British Journal of Pharmaceutical Research;4/16/2014, Vol. 4 Issue 4, p429 

    Aims: To investigate the effects of M. charantia on serum lipid profile, serum protein concentration and selected markers of cardiovascular damage in streptozotocin-induced diabetic Wistar rats. Study design: Forty healthy adult Wistar rats of both sexes were randomly assigned into five groups...

  • Blood from Grains. Breindl, Anette // BioWorld Today;11/7/2011, Vol. 22 Issue 216, Special section p2 

    The article reports that scientists from Wuhan University in China have produced recombinant human serum albumin from rice.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics