Value of124I-PET/CT in staging of patients with differentiated thyroid cancer

Freudenberg, L.; Antoch, G.; Jentzen, W.; Pink, R.; Knust, J.; Görges, R.; Müller, S.; Bockisch, A.; Debatin, J.; Brandau, W.
November 2004
European Radiology;Nov2004, Vol. 14 Issue 11, p2092
Academic Journal
The aim of this study is to evaluate the clinical significance of124I positron emission tomography (PET) using a combined PET/CT tomograph in patients with differentiated thyroid carcinoma and to compare the PET/CT results with131I whole-body scintigraphy (WBS), dedicated PET and CT alone. Twelve thyroid cancer patients were referred for diagnostic workup and entered complete clinical evaluation, including histology, cytology, thyroglobulin level, ultrasonography, fluorine-18 fluorodeoxyglucose (FDG)-PET, FDG-PET/CT and CT. Lesion-based evaluation showed a lesion delectability of 56, 87 and 100% for CT,124I-PET, and combined124I-PET/CT imaging, respectively. Lesion delectability of131I-WBS was 83%. We conclude that124I-PET/CT imaging is a promising technique to improve treatment planning in thyroid cancer. It is particularly valuable in patients suffering from advanced differentiated thyroid cancer prior to radio-iodine therapy and in patients with suspected recurrence and potential metastatic disease.


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