TITLE

Macaque animal model for HIV-induced neurological disease

AUTHOR(S)
Sopper, S.; Koutsilieri, E.; Scheller, C.; Czub, S.; Riederer, P.; ter Meulen, V.
PUB. DATE
May 2002
SOURCE
Journal of Neural Transmission;May2002, Vol. 109 Issue 5/6, p747
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Summary. The pathogenesis of HIV-induced neurological disorders is still incompletely understood. Since many aspects of this disease are difficult to explore in humans, animal models are necessary to fill the gaps in our knowledge. Based on the high concordance with the human system, the SIV-infection of macaques currently provides the best animal model to study pathogenesis, therapy and prevention of HIV-infection. In this review, important features of the CNS-infection in this model are outlined. Recent virological, immunological, neurophysiological and neurochemical findings obtained with this animal model are presented and key factors in the development of neurological disease are identified.
ACCESSION #
15397244

 

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