TITLE

Memory deficits and increased emotionality induced by β-amyloid (25–35) are correlated with the reduced acetylcholine release and altered phorbol dibutyrate binding in the hippocampus

AUTHOR(S)
Olariu, A.; Tran, M. H.; Yamada, K.; Mizuno, M.; Hefco, V.; Nabeshima, T.
PUB. DATE
September 2001
SOURCE
Journal of Neural Transmission;Sep2001, Vol. 108 Issue 8/9, p1065
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Summary. In the present study we found that chronic infusion of β-amyloid fragment (25–35) at nanomolar concentration into rat cerebral ventricle impairs learning and memory. At a concentration of 3 nmol/day but not 0.3 nmol/day, β-amyloid significantly reduced the spontaneous alternation behavior and the memory performance in the water maze and multiple passive avoidance tests. A significant increase in anxiety was also found in the animals infused with 3 nmol/day β-amyloid fragment. Memory deficits and the increased emotionality were correlated with a decreased nicotine-evoked acetylcholine release from the frontal cortex/hippocampus, as assessed by microdialysis, in freely moving rats. The amyloid fragment infused either at pico- or nanomolar concentrations reduced the affinity of [3H] phorbol dibutyrate binding, an index of activated protein kinase C (PKC), and increased the total number of binding sites in the hippocampal particulate fraction. Our results suggest that the amnesic and anxiogenic effects of chronic infusion of β-amyloid (25–35) are related to the decreased acetylcholine release and reduced PKC activation.
ACCESSION #
15394871

 

Related Articles

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics