Autosomal-dominant Parkinson's disease linked to 2p13 is not caused by mutations in transforming growth factor alpha (TGF alpha)

Zink, M.; Grimm, L.; Wszolek, Z. K.; Gasser, T.
September 2001
Journal of Neural Transmission;Sep2001, Vol. 108 Issue 8/9, p1029
Academic Journal
Summary. A susceptibility gene for Parkinson's disease (PD) with late onset and typical Lewy-body pathology maps to chromosome 2p13 (PARK3). In the present study we examined the gene for transforming growth factor alpha (TGF alpha), which is located in the PARK3-region, as a potential candidate gene. This polypeptide mitogen exerts trophic actions on dopaminergic neurons and TGF alpha-deficient mice have fewer dopaminergic neurons. We did not find mutations in the exonic or exon-flanking intronic sequences of index patients of two families linked to 2p13. This result excludes mutations in the coding region of TGF alpha as a cause for hereditary PD, but does not rule out a possible role of sequence variants in regulatory regions or splice sites.


Related Articles

  • LRRK2 in Parkinson's disease and dementia with Lewy bodies. Xiongwei Zhu; Babar, Asim; Siedlak, Sandra L.; Qiwei Yang; Ito, Genta; Iwatsubo, Takeshi; Smith, Mark A.; Perry, George; Chen, Shu G. // Molecular Neurodegeneration;2006, Vol. 1, p17 

    Background: Mutations in LRRK2 encoding leucine-rich repeat kinase 2 are thus far the most frequent genetic cause associated with autosomal dominant and idiopathic Parkinson's disease (PD). To examine whether LRRK2 is directly associated with neuropathology of PD and other related disorders, we...

  • Clinical and neuropathological correlates of Lewy body disease. Hishikawa, Nozomi; Hashizume, Yoshio; Yoshida, Mari; Sobue, Gen // Acta Neuropathologica;Apr2003, Vol. 105 Issue 4, p341 

    We investigated distribution of neuronal and glial inclusions in 30 brains obtained at autopsy from patients with Lewy bodies (LBs) disease, which was clinically diagnosed as Parkinson's disease (PD), dementia with Lewy bodies (DLB), or pure autonomic failure (PAF). The cases were classified,...

  • Parkinson’s disease: clinical aspects. Klockgether, Thomas // Cell & Tissue Research;Oct2004, Vol. 318 Issue 1, p115 

    Parkinsonism is a clinical syndrome characterized by akinesia, muscular rigidity, and resting tremor. The most frequent cause of parkinsonism is Parkinson’s disease (PD). Progressive loss of substantia nigra neurons together with the occurrence of Lewy bodies are considered essential...

  • Dementia with Lewy Bodies vs. Alzheimer's Disease. Dementia, Frank C. // American Family Physician;6/1/2004, Vol. 69 Issue 11, p2688 

    Presents information on dementia with Lewy Bodies (DLB). Symptoms of the disease; Clinical criteria for DLB; Medications used in the treatment of patients with DLB; Discussion on motor parkinsonism, a core feature of dementia; Management of the psychotic features of dementia.

  • A Role for TGF-β Signaling in Neurodegeneration: Evidence from Genetically Engineered Models. Tesseur, Ina; Wyss-Coray, Tony // Current Alzheimer Research;Dec2006, Vol. 3 Issue 5, p505 

    Neurodegenerative diseases including Alzheimer's disease (AD) and Parkinson's disease (PD) afflict growing numbers of people but treatments are not available or ineffective. These diseases are characterized by the loss of specific neuronal populations, the accumulation of protein aggregates...

  • Lewy body pathology in long-term fetal nigral transplants: is parkinson's disease transmitted from one neural system to another? Kordower, Jeffrey H; Brundin, Patrik // Neuropsychopharmacology;Jan2009, Vol. 34 Issue 1, p254 

    The article reports on the study looking for the possibility of Parkinson's disease being transmitted among neural systems. The Lewy body pathology in long-term fetal nigral transplants is believed to be the key in creation of modern anatomical tools towards understanding Parkinson's disease and...

  • Diagnostic and Pathophysiological Impact of FP-CIT SPECT in Parkinson 's Disease. Spiegel, Jorg // Central Nervous System Agents in Medicinal Chemistry;Sep2007, Vol. 7 Issue 3, p173 

    Idiopathic Parkinson's disease (PD) is characterized by a Lewy body-degeneration of presynaptic nigrostriatal dopaminergic neurons. This degeneration can be visualized by nuclear medicine methods, primarily by FP-CIT SPECT: Fluoropropyl-Carbomethoxy-Iodophenyl-Tropan (FP-CIT), marked by...

  • Sonographic discrimination of dementia with Lewy bodies and Parkinson's disease with dementia. Walter, Uwe; Dressler, Dirk; Wolters, Alexander; Wittstock, Matthias; Greim, Brigitte; Benecke, Reiner // Journal of Neurology;Apr2006, Vol. 253 Issue 4, p448 

    Objective: To study the use of transcranial sonography (TCS) in discriminating between patients with dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD). Methods: Fourteen patients with DLB, 31 with PDD and 73 with PD without dementia (PDnD) were studied with TCS....

  • Stages in the development of Parkinson’s disease-related pathology. Braak, Heiko; Ghebremedhin, Estifanos; Rüb, Udo; Bratzke, Hansjürgen; Tredici, Kelly // Cell & Tissue Research;Oct2004, Vol. 318 Issue 1, p121 

    The synucleinopathy, idiopathic Parkinson’s disease, is a multisystem disorder that involves only a few predisposed nerve cell types in specific regions of the human nervous system. The intracerebral formation of abnormal proteinaceous Lewy bodies and Lewy neurites begins at defined...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics