TITLE

Glutamate is not involved in the MPP+-induced dopamine overflow in the striatum of freely moving C57BL/6 mice

AUTHOR(S)
Uezono, T.; Matsubara, K.; Shimizu, K.; Mizukami, H.; Ogawa, K.; Saito, O.; Hayase, N.; Eto, H.; Kimura, K.; Shiono, H.
PUB. DATE
September 2001
SOURCE
Journal of Neural Transmission;Sep2001, Vol. 108 Issue 8/9, p899
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Summary. The role of glutamate in the N-methyl-4-phenyl-dihydropyridinium (MPP+) toxicity has been argued in the past decade. However, the effects of glutamate efflux and NMDA antagonist on MPP+-induced dopamine overflow have not been documented. To clarify this, we perfused MPP+ through a microdialysis probe in the striatum of freely moving mature C57BL/6 mice. The 60-min perfusion of 10 and 100 μM MPP+ strikingly increased dopamine levels to 28- and 93-fold of the basal values, respectively. In contrast, an administration of MPP+ did not induce marked glutamate release: the MPP+-perfusion slightly increased the glutamate level at 100 μM, but not at 10 μM. The addition of 100 μM (+)-MK-801 or 200 μM (±)-AP-7 to the perfusate did not attenuate MPP+-induced dopamine overflow. The extent of dopamine release only depended on the amount of MPP+ accumulation into the cells. These results indicated that, at least in the striatum, neither glutamate release nor the NMDA antagonist, including (+)-MK-801, could regulate MPP+-evoked dopamine overflow.
ACCESSION #
15394858

 

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