TITLE

Radiochemical analysis of the polar agrochemicals validamycin and the metabolite melamine by ion-exchange chromatography

AUTHOR(S)
Fredenhagen, A.
PUB. DATE
August 2004
SOURCE
Journal of Radioanalytical & Nuclear Chemistry;Aug2004, Vol. 261 Issue 2, p249
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Suitable analytical methods to determine the radiochemical purity of validamycin and melamine are not described in the literature. High performance ion-exchange chromatography for the detection of underivatized validamycin and melamine has been proposed. The compounds were separated on HPLC using a styrene-divinylbenzene copolymer based cation-exchanger. For the separation of validamycin a resin in the hydrogen-form has given a good separation and for melamine in the Na+-form. For the first time an ion-exchange separation of validamycin is described allowing the separation of at least four components of commercial validamycin: validamycin A, validamycin B or G, validoxylamine A and validoxylamine B or G without prior derivatization. The methods were applied to determine the radiochemical purity of 14C- or 3H labeled compounds.
ACCESSION #
15341833

 

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