Optoacoustic imaging using interferometric measurement of surface displacement

Carp, Stefan A.; Guerra III, Arnold; Duque Jr., Samuel Q.; Venugopalan, Vasan
December 2004
Applied Physics Letters;12/6/2004, Vol. 85 Issue 23, p5772
Academic Journal
We describe an optoacoustic imaging technique based on time-resolved measurements of laser-induced thermoelastic expansion. Tomographic images of tissue phantoms are formed using such measurements made at several locations following irradiation with a Q-switched Nd:YAG (λ=1064 nm) laser pulse. Our system is based on a modified Mach–Zehnder interferometer that measures surface displacement with a temporal resolution of 4 ns and a displacement sensitivity of 0.3 nm. Images formed from data sets acquired from several highly scattering tissue phantoms provide better than 200 μm resolution and show great promise for high-resolution noninvasive imaging of heterogeneous tissues at depths approaching 1 cm.


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