Systematic reviews of diagnostic test evaluations: What's behind the scenes?

Humphrey, Peter R.
November 2004
ACP Journal Club;Nov/Dec2004, Vol. 141 Issue 3, pA-14
Academic Journal
The article presents systematic reviews of diagnostic test evaluations. The article adds that the inter- and intraobserver variability of the gold standard must be known before one can assess any new test. No new test can be expected to match the gold standard more closely than the inter- and intraobserver variability for that gold standard. Failure to appreciate this limitation will result in a new test not matching the gold standard, even when the new test is as good, and sometimes better than, die gold standard.


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