TITLE

COMMENTARY: Lactulose or lactitol may improve hepatic encephalopathy but may be less effective than antibiotics

AUTHOR(S)
Korula, Jacob
PUB. DATE
November 2004
SOURCE
ACP Journal Club;Nov/Dec2004, Vol. 141 Issue 3, p59
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article presents a commentary on the study which concluded that lactulose or lactitol may improve hepatic encephalopathy (HE) but may be less effective than antibiotics.In acute liver failure, cerebral edema is the predominant cause of HE, with rapid progression to herniation if liver failure is irreversible. In advanced cirrhosis, HE is caused predominantly by the toxic effect of brain ammonia and by portosystemic shunting. The salutary effect of catharsis or antibiotic therapy in HE treatment is due to the reduction in blood ammonia levels caused by decreases in colonic bacterial populations.
ACCESSION #
15303571

 

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