Cadmium-Induced Changes in Hematology and 2,3-DPG Levels in Rats

Kłapcińska, B.; Poprzecki, S.; Dolezych, B.; Kimsa, E.
January 2000
Bulletin of Environmental Contamination & Toxicology;Jan2000, Vol. 64 Issue 1, p93
Academic Journal
This article presents information related to Cadmium (Cd)-Induced changes in Hematology and 2,3--DPG levels in Rats. Next to smoking ingestion of cadmium contaminated water and food is the most important source of cadmium in the non-industrially exposed subjects. After being absorbed from the gut, cadmium is transported with blood to other parts of the body. It was revealed in animal experiments that after chronic exposure it is mainly accumulated in liver and kidneys. In blood of intoxicated animals, cadmium is found in erythrocytes where it is bound to a low-molecular-weight protein, Cd-metallothionein.


Related Articles

  • Effects of Cadmium and Parathion Exposure on Hematology and Blood Biochemistry of Adult Male Rats. Guilhermino, L.; Soares, A. M. V. M.; Carvalho, A. P.; Lopes, M. C. // Bulletin of Environmental Contamination & Toxicology;Jan98, Vol. 60 Issue 1, p52 

    The article discusses the alteration of hematological and blood biochemistry of adult male Wistar rats due to cadmium and parathion exposure. A mixture of cadmium dissolved in nanopure water and parathion diluted in corn oil were injected into the rodents at a single dose, and several of the...

  • Biochemical changes induced by ethyl acetate in blood and liver of rat Srivastava, S. P.; Seth, P. K. // Bulletin of Environmental Contamination & Toxicology;Nov1974, Vol. 12 Issue 5, p612 

    No abstract available.

  • Effect of cadmium on liver regeneration after partial hepatectomy inrats Margeli, Alexandra; Theocharis, Stamatios; Mykoniatis, Michael; Skopelitou, Antigone; Skaltsas, Spyridon // Environmental Health Perspectives Supplements;1994 Supplement 3, Vol. 102, p273 

    No abstract available.

  • Hepatoprotective Effect of Arctium lappa Root Extract on Cadmium Toxicity in Adult Wistar Rats. Souza Predes, Fabricia; Silva Diamante, Maria; Foglio, Mary; Camargo, Camila; Aoyama, Hiroshi; Miranda, Silvio; Cruz, Bread; Gomes Marcondes, Maria; Dolder, Heidi // Biological Trace Element Research;Aug2014, Vol. 160 Issue 2, p250 

    This study was performed to determine the effects of Arctium lappa ( Al) to protect against cadmium damage in the rat liver. Male rats received a single i.p. dose of CdCl (1.2 mg/kg body weight (BW)) with or without Al extract administered daily by gavage (300 mg/kg BW) for 7 or 56 days. After 7...

  • Differential Hepatotoxicity Induced by Cadmium in Fischer 344 and Sprague-Dawley Rats. Kuester, Robert K.; Waalkes, Michael P.; Goering, Peter L.; Fisher, Ben L.; McCuskey, Robert S.; Sipes, I. Glenn // Toxicological Sciences;Jan2002, Vol. 65 Issue 1, p151 

    A number of reports document that Fischer 344 (F344) rats are more susceptible to chemically induced liver injury than Sprague-Dawley (SD) rats. Cadmium (CdCl2), a hepatotoxicant that does not require bioactivation, was used to better define the biological events that are responsible for the...

  • 131I Induced Hematological Alterations in Rat Blood: Protection by Zinc. Vijayta Dani; Anshoo Malhotra; D. Dhawan // Biological Trace Element Research;Dec2007, Vol. 120 Issue 1-3, p219 

    The present study was planned to determine the potential of zinc in attenuating the toxicity induced by 131I in rat blood. Female wistar rats were segregated into four main groups. Animals in Group I served as normal controls; Group II animals were administered a dose of 3.7 Mbq of 131I...

  • The Protective Nature of Garlic, Ginger and Vitamin E on CCI4-Induced Hepatotoxicity in Rats. Patrick-Iwuanyanwu, K. C.; Wegwu, M. O.; Ayalogu, E. O. // Asian Journal of Biochemistry;2007, Vol. 2 Issue 6, p409 

    The protective nature of garlic, ginger and vitamin E on CCl4-induced liver damage in rats were investigated using selected haematological indices: PCV, Hb, WBC, polymorphonuclear cells and lymphocytes. PCV was lowest in rats administered garlic-ginger (1:2) and CCl4 (0.5 mL kg-1 bw) with a mean...

  • Transmission Electron Microscopy Study of the Effects of Cadmium and Copper on Fetal Rat Liver Tissue. E. Oguzhan Oguz; Gülçin Abban; Recep Kutlubay; Sebahat Turgut; Yasar Enli; Deniz Erdogan // Biological Trace Element Research;Feb2007, Vol. 115 Issue 2, p127 

    During the entire period of their pregnancies, three groups of adultpregnant Wistar albino rats were provided with tap water (control; groupI) or with tap water containing 10 mg/kg CdCl2 (group II) or 10 mg/kgCdCl2 plus 10 mg/kg CuSO4 (group III). At term, the animals were sacrificedand the...

  • RESPONSE OF THE RAT ORGANISM TO THE CHRONIC EXPOSURE OF CADMIUM LOW DOSES DURING THE ANTENATAL PERIOD. Mirzoev, E. B.; Kobyalko, V. O.; Gubina, O. A.; Frolova, N. A. // Toxicological Review;2014, Vol. 127 Issue 4, p29 

    Chronic exposure to low doses of cadmium in the antenatal period leads to the development of negative reactions in the rat liver (generation F1) within the first 30 day of investigation. In the subsequent time periods of observation, a reversible character of changes was noted.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics