TITLE

Stability of L-[S-methyl-11C]methionine solutions

AUTHOR(S)
Bogni, A.; Bombardieri, E.; Iwata, R.; Cadini, L.; Pascali, C.
PUB. DATE
May 2003
SOURCE
Journal of Radioanalytical & Nuclear Chemistry;May2003, Vol. 256 Issue 2, p199
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
For clinical PET studies L-[S-methyl-11C]methionine ([11C]MET) solutions have been prepared in both high doses and specific activities (up to 48.1 GBq and 370 GBq/mmol, respectively) with high radiochemical purity (>99%). The stability of these preparations was investigated by HPLC to ensure the radiopharmaceutical efficacy during the usable shelf life. Under our routine conditions the observed radiochemical purity loss never exceeded 3.5% one hour after EOS. The decomposition rate was affected by total activity and chemical composition of the solutions.
ACCESSION #
15194474

 

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