Identification of Barrett's Esophagus in Relatives by Endoscopic Screening

Chak, Amitabh; Faulx, Ashley; Kinnard, Margaret; Brock, Wendy; Willis, Joseph; Wiesner, Georgia L.; Parrado, Antonio R.; Goddard, Katrina A. B.
November 2004
American Journal of Gastroenterology;Nov2004, Vol. 99 Issue 11, p2107
Academic Journal
AIM: Familial aggregation of Barrett's esophagus and its associated cancers has been termed familial Barrett's esophagus (FBE). The aim of the study was to determine whether endoscopic screening would identify Barrett's esophagus (BE) in relatives of probands with BE or esophageal adenocarcinoma (EAC). METHODS: All living first-degree relatives of patients with long segment BE or EAC presenting to the endoscopy suite of two academic hospitals were sent validated questionnaires inquiring about gastroesophageal reflux symptoms and prior endoscopic evaluation. First-degree relatives of affected probands or affected relatives who reported no prior upper endoscopy were offered screening unsedated esophagoscopy. Relatives with chronic gastroesophageal reflux symptoms were also offered an alternative of conventional sedated upper endoscopy. The yield of screening endoscopy was measured. Screening endoscopy findings were then compared between family members of known FBE patients and those with "isolated" disease. RESULTS: One hundred and ninety-eight relatives from 69 families, 23 known FBE probands and 46 probands with apparently "isolated" disease, were enrolled. Forty relatives (29 FBE relatives and 11 relatives of probands with "isolated" disease) reported prior upper endoscopy. Screening upper endoscopies performed on 62 (25 FBE and 37 "isolated" disease relatives) of the remaining 158 relatives identified Barrett's epithelium in 13 (21%). Compared to probands with apparently "isolated" disease, Barrett's epithelium (EAC, BE, or SSBE) was identified significantly more often in siblings and offspring of FBE probands, p ≤ 0.05. Endoscopic screening of relatives of FBE probands identified a multigeneration multiplex FBE pedigree consistent with an autosomally dominant inherited trait. Endoscopic screening of relatives of probands with reported "isolated" diseased did not identify any new FBE pedigrees. CONCLUSIONS: Endoscopy identified EAC, long-segment BE, and short-segment BE in a substantial proportion of first-degree relatives of affected members of FBE families. A familial susceptibility to develop Barrett's epithelium appears to be present in a subset of patients with BE and EAC.


Related Articles

  • Capsule Endoscopy: What Can We Expect? Ricer, Rick E.; Li, Christina // Journal of Family Practice;Dec2005 Supplement, Vol. 54, p15 

    The article presents a discussion of the advantages and disadvantages of capsule endoscopy for the diagnosis and treatment of gastroesophageal reflux disease related complications. Endoscopy can now be done using an esophageal video capsule, which transmits and records digital images of the...

  • Barrett's esophagus. Cohen, Jacob T.; Postma, Gregory N.; Enriquez, Patrick S.; Koufman, James A. // ENT: Ear, Nose & Throat Journal;Jun2003, Vol. 82 Issue 6, p422 

    Presents the case of a man with a history of laryngopharyngeal reflux who underwent double-probe ambulatory pH testing. Finding from transnasal esophagoscopy; Occurrence of Barrett's esophagus; Appropriate treatment along with regular-interval surveillance with multiple biopsies.

  • When Is Esophageal Capsule Endoscopy Appropriate? Ricer, Rick E.; Eisen, Glenn M.; Rao, Goutham // Journal of Family Practice;Dec2005 Supplement, Vol. 54, p19 

    The article presents doctors' advise regarding the use of esophageal capsule endoscopy in three patients suffering from gastroesophageal reflux disease (GERD). In case of a 63-year old patient suffering from chronic GERD, the doctors advised for the esophageal capsule endoscopy to rule out...

  • Progression or regression of barrett's esophagus–is it all in the eye of the beholder? Dekel, Roy; Wakelin, Donald E.; Wendel, Chris; Green, Colleen; Sampliner, Richard E.; Garewal, Harinder S.; Martinez, Patricia; Fass, Ronnie // American Journal of Gastroenterology;Dec2003, Vol. 98 Issue 12, p2612 

    Accurate measurements of Barrett's esophagus length are important in clinical follow-up as well as in studies of therapeutic intervention in Barrett's esophagus. Our aim was to evaluate both the inter- and intraobserver reliability in measuring Barrett's length during two consecutive endoscopies...

  • Esophageal Dilation with Metal Olives Under Fiberoptic Endoscopic Control. Mangla, Jagdish C.; Kothari, Tarun // American Journal of Gastroenterology;Mar1980, Vol. 73 Issue 3, p260 

    Three patients with marked strictures (less than 20 Fr.) of the esophagus are described. It was very difficult to institute any simple program of dilation because mercury-filled Maloney bougies will buckle and rigid endoscopy with dilation carries a great risk of perforation. Using the...

  • Uncertain Benefit of Barrett's Esophagus Surveillance. Ebell, Mark // American Family Physician;1/1/2004, Vol. 69 Issue 1, p169 

    Highlights a study on the long-term endoscopic surveillance of patients with Barrett's esophagus. Clinical setting of the study; Study design; Discussion on the result of the study.

  • Capsule Endoscopy: New Applications. Eisen, Glenn M. // Journal of Family Practice;Dec2005 Supplement, Vol. 54, p9 

    The article focuses on capsule endoscopy and its application in the diagnosis of Barrett's esophagus and esophageal adenocarcinoma. Barrett's esophagus is one of the complications of gastroesophageal reflux disease (GERD). Barrett's esophagus results in inflammation and complications in the...

  • Low grade esophageal eosinophilia in adults: an unrecognized part of the spectrum of eosinophilic esophagitis? Ravi, Karthik; Talley, Nicholas; Smyrk, Thomas; Katzka, David; Kryzer, Lori; Romero, Yvonne; Arora, Amindra; Alexander, Jeffrey; Talley, Nicholas J; Smyrk, Thomas C; Katzka, David A; Arora, Amindra S; Alexander, Jeffrey A // Digestive Diseases & Sciences;Jul2011, Vol. 56 Issue 7, p1981 

    Background: Eosinophilic esophagitis (EoE) is defined by a minimum of 15 eosinophils (eos) per high-powered field (HPF) on esophageal biopsy, along with esophageal symptoms and the exclusion of gastroesophageal reflux (GERD). The clinical significance of fewer eosinophils is...

  • Dysphagia following cervical fusion. Otto, Kristen J.; Johns III, Michael M. // ENT: Ear, Nose & Throat Journal;Jun2005, Vol. 84 Issue 6, p344 

    Discusses a medical case concerning dysphagia following cervical fusion. Information on dysphagia; Result of the in-office transnasal esophagoscopy.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics