TITLE

Lopinavir Plasma Levels in Salvage Regimes by a Population of Highly Active Antiretroviral TherapyTreated HIV-1–Positive Patients

AUTHOR(S)
Torti, C.; Quiros-Roldan, E.; Tirelli, V.; Regazzi-Bonora, M.; Moretti, F.; Pierotti, P.; Orani, A.; Maggi, P.; Cargnel, A.; Patroni, A.; De Luca, A.; Carosi, G.
PUB. DATE
November 2004
SOURCE
AIDS Patient Care & STDs;Nov2004, Vol. 18 Issue 11, p629
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Increased lopinavir (LPV) exposure obtained in vivo through combination with low-dose ritonavir may overcome a certain grade of resistance but not all. We sought to analyze LPV variability and possible risk factors. LPV trough plasma concentrations were determined by highperformance liquid chromatography after 1, 4, and 12 weeks from salvage regimens and tested in both univariate and multivariate regression analyses with age, gender, weight, risk factors for HIV acquisition, hepatitis C virus reactivity, hepatitis B surface antigen positivity, baseline aspartate transferase (AST) or alanine transferase (ALT) levels, creatinine, non-nucleoside reverse transcriptase inhibitors (NNRTIs) or tenofovir as concomitant drugs, and NNRTIs administered in the previous regimen. Fifty-six patients were included into the study. Among them, 8 of 56 (14.3%) at week 1, 12 of 56 (21.4%) at week 4, and 9 of 56 (16.1%) at week 12 had suboptimal LPV plasma concentrations, defined as trough concentration less than 4 μg/mL. No correlation was found between LPV trough concentrations and assessed variables. In conclusion, pharmacokinetic variability and low LPV concentrations have been found, sup- porting the use of therapeutic drug monitoring in those starting this drug.
ACCESSION #
15179218

 

Related Articles

  • Population pharmacokinetics of ritonavir-boosted saquinavir regimens in HIV-infected individuals. Laura Dickinson; Marta Boffito; David J. Back; Saye H. Khoo; Anton L. Pozniak; Peter Mugyenyi; Concepta Merry; Reshma Saskia Autar; David M. Burger; Leon J. Aarons // Journal of Antimicrobial Chemotherapy (JAC);Dec2008, Vol. 62 Issue 6, p1344 

    : Objectives The aim of this study was to develop and validate a population pharmacokinetic model in order to describe ritonavir-boosted saquinavir concentrations dosed twice and once daily in human immunodeficiency virus (HIV)-infected patients from the UK, Uganda and Thailand and to identify...

  • The pharmacokinetics of liposomal encapsulated daunorubicin are not modified by HAART in patients with HIV-associated Kaposi's sarcoma. Fumagalli, Luca; Zucchetti, Massimo; Parisi, Idria; Viganò, Maria Grazia; Zecca, Bruno; Careddu, Anna; D'Incalci, Maurizio; Lazzarin, Adriano // Cancer Chemotherapy & Pharmacology;Jun2000, Vol. 45 Issue 6, p495 

    Purpose: To investigate the pharmacokinetics of liposomal daunorubicin (DaunoXome) administered alone or in combination with antiviral therapy including protease inhibitors (PI) to HIV-positive patients affected by Kaposi's sarcoma (KS). Patients and methods: A group of 18 patients with...

  • Antiretroviral Drugs in Pediatric HIV-Infected Patients. Phelps, B. Ryan; Rakhmanina, Natella // Pediatric Drugs;2011, Vol. 13 Issue 3, p175 

    Antiretroviral (ARY) therapy has been shown to achieve high therapeutic efficacy in treating pediatric HLV disease. The delivery of affordable, child friendly, and easy to store and administer ARV drugs is key to the successful management of HIV in children. In recent years, significant progress...

  • Evaluation of Saliva as an Alternative Matrix for Monitoring Plasma Zidovudine, Lamivudine and Nevirapine Concentrations in Rwanda. Gras, Alain; Schneider, Serge; Karasi, Jean-Claude; Ternes, Anne-Marie; Sauvageot, Nicolas; Karasi-Omes, Christine; Henry, Anne-Pascale; Schmit, Jean-Claude; Seguin-Devaux, Carole; Arendt, Vic // Current HIV Research;Jun2011, Vol. 9 Issue 4, p223 

    Saliva may provide interesting advantages as matrix for compliance measurements, pharmacokinetic studies and therapeutic drug monitoring in resource limited countries. We investigated the feasibility of using saliva for compliance monitoring of zidovudine (ZDV), lamivudine (3TC) and nevirapine...

  • Failure of Modified Directly Observed Therapy Combined with Therapeutic Drug Monitoring to Enhance Antiretroviral Adherence in a Patient with Major Depression. Goicoechea, Miguel; Best, Brookie; Seefried, Edward; Wagner, Glenn; Capparelli, Edmund; Haubrich, Richard // AIDS Patient Care & STDs;Apr2006, Vol. 20 Issue 4, p233 

    Improving medication nonadherence in HIV-infected patients with concomitant psychiatric issues remains a challenging therapeutic dilemma. One strategy may be to use a short course of modified directly observed therapy combined with therapeutic drug monitoring as an adherence intervention....

  • Representações sociais da Aids e da Terapia Anti-retroviral para pessoas vivendo com HIV. de Lucena Torres, Tatiana; Vizeu Camargo, Brígido // Psicologia: Teoria e Prática;jan-jun2008, Vol. 10 Issue 1, p64 

    The aim of this study was to characterize the social representation of Aids and Highly Active Antiretroviral Therapy (HAART) for people living with HIV that have adherence to treatment, users of the public health services of Florianópolis, Santa Catarina. All the participants (N = 60) showed...

  • State of the HAART: assess CV risk before initiation.  // Reactions Weekly;6/18/2005, Issue 1056, p3 

    Discusses research being done on highly active antiretroviral therapy (HAART) in patients with HIV-1 infections. Reference to a study by F. Moerman and colleagues published in the June 11, 2005 issue of the "British Medical Journal"; Reason for the assessment of cardiovascular risk in patients...

  • Eliminating Persistent HIV Infection: Getting to the End of the Rainbow. Margolis, David M.; Archin, Nancie M. // Journal of Infectious Diseases;6/15/2007, Vol. 195 Issue 12, p1734 

    This article comments on challenges that the medical fraternity faces to eradicate established HIV infection. The article makes specific reference to the study "Decay of the HIV Reservoir in Patients Receiving of Antiretroviral Therapy for Extended Periods: Implications for Eradication of...

  • HIV associated nephropathy: a treatable condition. Brook, M Gary; Miller, Robert F // Sexually Transmitted Infections;Apr2001, Vol. 77 Issue 2, p97 

    Objectives: To describe current knowledge on the aetiology, pathology, diagnosis, and treatment of HIV associated nephropathy. Methods: A Medline search was performed using the key words "HIV," "nephropathy," "renal," and "kidney." A further search was performed for each of the currently...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics