Casey, Richard
October 1998
Canadian Journal of Human Sexuality;Fall98, Vol. 7 Issue 3, p203
Academic Journal
The article describes the physiological processes involved in penile erection and uses this information to explain the mode of action of oral medications used in the treatment of erectile dysfunction (ED). The high prevalence of erectile dysfunction (ED) in North America has been well documented, as have the various biomedical treatments used in treatment. The emergence of sildenafil (Viagra), an effective, easy to-use, and relatively low risk oral medication, has given this issue wide publicity and, in the process, altered the landscape for public and professional education about ED and its treatment. Since ED can cause considerable distress, it was assumed that many men were not seeking treatment due to embarrassment, resignation, acceptance or discomfort with the available treatment methods. Pharmacological agents can facilitate erection by enhancing the natural processes that induce erection or by inhibiting the processes that maintain flaccidity. The preceding observations indicate that sexual arousal in men involves a complex interaction of physiological and subjective processes.


Related Articles

  • Sildenafil: from the bench to the bedside. Michelakis, Evangelos // CMAJ: Canadian Medical Association Journal;10/31/2000, Vol. 163 Issue 9, p1171 

    Erectile dysfunction affects a large segment of the male population, and in most cases impaired relaxation of the smooth muscle cells in the corpus cavernosum and the penile arteries is a factor. Sildenafil, a relatively specific vasodilator of the penile circulation, has revolutionized the...

  • Rebuilding the male machine. Cowley, Geoffrey; Rogers, Adam // Newsweek;11/17/1997, Vol. 130 Issue 20, p67 

    Focuses on the findings of research into the mechanics of male sex organs and the treatment of sexual impotence. Advances in understanding since the 1970s; Mechanism of a male erection; Diseases that can adversely affect male sexual function; Treatments that are available in late 1997. INSET:...

  • Guest Editor's Note. Heaton, Jeremy P. W. // Journal of Sex Education & Therapy;1998, Vol. 23 Issue 3, p185 

    The author reflects on the launching of Viagra as an oral therapy for erectile dysfunction (ED). He states that there was an understanding among researchers and clinicians of the impact that effective oral therapy for ED would likely have on clinical practice and patient experience. He asserts...

  • Oral sildenafil (Viagra) in male erectile dysfunction: use, efficacy and safety profile in an unselected cohort presenting to a British district general hospital. Sairam, Krishnamurthy; Kulinskaya, Elena; Hanbury, Damian; Boustead, Gregory; McNicholas, Thomas // BMC Urology;2002, Vol. 2, p4 

    Introduction: Sildenafil (Viagra®) is one of the drugs used in the first line therapy of male erectile dysfunction (MED). We have recorded outcomes, adverse events and acceptability of Sildenafil (Viagra) therapy in an unselected group of men presenting with ED to a British district general...

  • Erectile dysfunction.  // Mayo Clinic Health Letter;Nov2016, Vol. 34 Issue 11, p1 

    The article presents information on erectile dysfunction, its causes, and treatment. Topics include an understanding of how an erection occurs in the presence of normal levels of hormones, cardiovascular disease as an underlying factor of erectile dysfunction, and the effect of other problems...

  • Erectile Dysfunction Therapy: Back Country Implications and Risks. Wilson, Torrence M. // Wilderness & Environmental Medicine;Spring2008, Vol. 19 Issue 1, p67 

    Erectile dysfunction (ED) is a common problem, with 20 to 30 million American men affected in varying degrees. Beyond this some therapies, particularly oral medication, are being employed for enhanced performance by younger men with normal sexual function. Advances and improved understanding of...

  • Pharmacological profile of a nitric oxide donor spermine NONOate in the mouse corpus cavernosum. ERTUĞ, Fatma Peyman; ŞİNGİRİK, Erğin; BÜYÜKNACAR, Hacer Sinem; GÖÇMEN, Cemil; SEÇİLMİŞ, Mehmet Ata // Turkish Journal of Medical Sciences;2014, Vol. 44 Issue 4, p569 

    Background/aim: To investigate the effects of spermine NONOate in the cavernous tissue obtained from mice treated or untreated with sildenafil. Materials and methods: We studied the effects of spermine NONOate on the tone and nitrergic relaxation responses of isolated mouse corpus cavernosum and...

  • The Pharmacologic Management of Erectile Dysfunction: Sildenafil Citrate (Viagra). Padma-Nathan, Harin // Journal of Sex Education & Therapy;1998, Vol. 23 Issue 3, p207 

    Sildenafil citrate (Viagra) is the first effective, orally administered agent for the management of erectile dysfunction (ED). It is a potent and selective inhibitor of phosphodiesterase type 5 (PDE5), the predominant isoform found in human corporal smooth muscle. Sexual stimulation releases, in...

  • Chapter 8What to do when oral treatment fails?  // International Journal of Impotence Research;Dec2003 Supplement 7, Vol. 15, pS30 

    The article discusses the problem of oral treatment failure. In view of a patient that claims to have tried the tablet and achieved no result, several steps should be taken before classifying him as a nonresponder. There are several reports showing that up to 56 percent of patients labeled...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics