TITLE

Sensitive flow-injection chemiluminescence determination of terbutaline sulfate based on enhancement of the luminol—permanganate reaction

AUTHOR(S)
Zhouping Wang; Zhujun Zhang; Zhifeng Fu; Xiao Zhang
PUB. DATE
February 2004
SOURCE
Analytical & Bioanalytical Chemistry;Feb2004, Vol. 378 Issue 3, p834
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A novel and highly sensitive chemiluminescence (CL) method for the determination of terbutaline sulfate, coupled with flow-injection analysis (FIA), is described in this paper. The method is based on enhancement by terbutaline sulfate of the chemiluminescence emission of the luminol–permanganate system under alkaline conditions. Under the conditions selected the concentration of terbutaline sulfate is proportional to CL intensity in the range 5×10-10–5×10-7 g mL-1, with a detection limit of 1.7×10-10 g mL-1 (3σ). The relative standard deviation is 2.8% for 1×10-8 g mL-1 terbutaline sulfate (n=11). Ninety samples can be determined per hour. The proposed method has been used to determine terbutaline sulfate in pharmaceutical preparations and in plasma and urine samples with satisfactory results. The possible mechanism of the chemiluminescence reaction is discussed briefly.
ACCESSION #
15125780

 

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