TITLE

Potential parameters for the detection of hGH doping

AUTHOR(S)
Kniess, A.; Ziegler, E.; Kratzsch, J.; Thieme, D.; Müller, R. K.
PUB. DATE
July 2003
SOURCE
Analytical & Bioanalytical Chemistry;Jul2003, Vol. 376 Issue 5, p696
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The aim of our hGH application study with non-competitive athletes was the investigation of selected serum parameters from different processes affected by hGH. Fifteen athletes (age 21–33, mean 24) were treated with 0.06 IU hGH/kg BW per day or placebo (10 hGH, 5 placebo) respectively for 14 days. Blood samples were taken prior to, during and until 10 weeks after treatment. The concentrations of the following markers were determined in relevant serum samples: IGF-I, IGFBP-3, ALS, PIIINP, PINP, osteocalcin, and leptin. The IGF-I concentration increased rapidly within the hGH treatment group and showed significantly higher levels compared to baseline even 3 days after application. The response of the IGFBP-3 to the hGH applications was lower in comparison to IGF-I. The hGH group showed an increasing IGFBP-3 compared to baseline from day 4 till day 15. The response of PIIINP to hGH is clearly delayed compared to the IGF-I axis, but the PIIINP concentration remains on an increased level for a longer period (from day 4 until day 21). The time course and the extent of response varied strongly interindividually. PINP and osteocalcin showed only a small response to hGH applications. These parameters are characterised by a strong scattering of base values compared with the small response. In the hGH treatment group very different leptin concentrations were found at the beginning of the study, but after treatment decreasing leptin levels were observed in all cases. The determination of only one parameter will not be sufficient for detection of hGH abuse. A combination of markers by mathematical methods can be helpful to distinguish between placebo and hGH-treated athletes. By using the suggested discriminant function the data sets of hGH and placebo-treated athletes could be separated without false positive results.
ACCESSION #
15125673

 

Related Articles

  • INSIGHTS SPECIALITY CHEMICALS. Sivaramakrishnan, C. N. // Colourage;Nov2008, Vol. 55 Issue 11, p40 

    The article provides information on biocides which are used to kill the growth of living organisms in industrial and consumer products. Biocides are divided into five classes including bactericides, insecticides and algaecides. Biocides' major application include personal care, inks and coatings...

  • Microbial Diversity Studies at the Winogradsky Institute of Microbiology. Zavarzin, G. A. // Microbiology (00262617);Sep2004, Vol. 73 Issue 5, p509 

    Due to a chain of circumstances, some of them caused by unfavorable events, the Institute of Microbiology, Russian Academy of Sciences (INMI), continued the tradition of the “golden age” of microbiology of Winogradsky's time. Interest was focused on the functional diversity of...

  • Modeling of the Process of Pyrolysis of Shale Particles. Gerasimov, G. Ya. // Journal of Engineering Physics & Thermophysics;Nov/Dec2003, Vol. 76 Issue 6, p1310 

    Based on an analysis of experimental data on the pyrolysis of Baltic shale, a kinetic model of the process with allowance for the polydispersity of fuel particles, secondary chemical reactions, and fragmentation of the particles has been constructed.

  • Synthesis and Stereochemistry of Some 3-Azabicyclo[3.3.1]nonane Derivatives. Vafina, G. F.; Yakhina, G. R.; Khakimova, T. V.; Spirikhin, L. V.; Galin, F. Z.; Yunusov, M. S. // Russian Journal of Organic Chemistry;Jan2003, Vol. 39 Issue 1, p49 

    Michael reactions of methyl (ethyl) 1-benzyl-4-oxopiperidine-3-carboxylates with a number of α,β-unsaturated carbonyl compounds result in formation of 6- and 6,8-substituted methyl (ethyl) 3-benzyl-9-oxo-3-azabicyclo[3.3.1]nonane-1-carboxylates. Stereochemical aspects of these reactions...

  • Tin Oxide Precursor Chemistry and Its Link to Coating Properties. van Mol, A. M. B.; Alcott, G. R.; Allendorf, M. D. // American Ceramic Society Bulletin;Jan2005, Vol. 84 Issue 1, p37 

    Focuses on the aid of the interpretation of the CVD process and it's influence on layer properties in optimizing manufacturing processes. Determination of the chemical and microstructural features of the substrate, the final properties of the layer; Consideration of chemical reactions in...

  • New Carbene-Based Catalyst Simplifies Chemical Preparations. Chiarello, Kaylynn // Pharmaceutical Technology;Oct2005, Vol. 29 Issue 10, p26 

    Reports on a carbene-based catalyst that makes chemical reactions faster and more economical. Attachment of carbenes to certain metals; Lessening of reaction costs; Benefits in drug manufacturing.

  • Mechanical and fracture properties of epoxy/inorganic micro- and nano-composites. Kinloch, A. J.; Taylor, A. C. // Journal of Materials Science Letters;Oct2003, Vol. 22 Issue 20, p1439 

    This article focuses on the mechanical and fracture properties of epoxy/inorganic micro- and nano-composites. In recent years the concept of forming hybrids using polymers and inorganic materials has received a significant amount of attention. Many claims for the potential of these organic/...

  • Chemical tuning polymorphology of functional materials by hydrothermal and solvothermal reactions. Yan, Chenglin; Zou, Longjiang; Xue, Dongfeng; Xu, Jiasheng; Liu, Meinan // Journal of Materials Science;Apr2008, Vol. 43 Issue 7, p2263 

    Both hydrothermal and solvothermal reactions have been employed to chemically tune the polymorphology of functional materials, such as ZnO, ZnS, BaCO3, magnesium salts, copper salts, and lithium niobate. Novel self-assembled nest-like Mg5(CO3)4(OH)2·4H2O microspheres are formed without any...

  • Dynamics of chemically powered nanodimer motors subject to an external force. Yu-Guo Tao; Kapral, Raymond // Journal of Chemical Physics;7/14/2009, Vol. 131 Issue 2, p024113 

    The chemically powered self-propelled directed motions of nanodimer motors confined in a rectangular channel and subject to an applied external conservative force are investigated using hybrid molecular dynamics/multiparticle collision dynamics. The influence of factors, such as dimer sizes,...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics