Sampling strategies exploiting multi-pumping flow systems

Prior, João A. V.; Santos, João L. M.; Lima, José L. F. C.
April 2003
Analytical & Bioanalytical Chemistry;Apr2003, Vol. 375 Issue 8, p1234
Academic Journal
In this work new strategies were exploited to implement multi-pumping flow systems relying on the utilisation of multiple devices that act simultaneously as sample-insertion, reagent-introduction, and solution-propelling units. The solenoid micro-pumps that were initially used as the only active elements of multi-pumping systems, and which were able to produce pulses of 3 to 25 μL, were replaced by syringe pumps with the aim of producing pulses between 1 and 4 μL. The performance of the developed flow system was assessed by using distinct sample-insertion strategies like single sample volume, merging zones, and binary sampling in the spectrophotometric determination of isoniazid in pharmaceutical formulations upon reaction with 1,2-naphthoquinone-4-sulfonate, in alkaline medium. The results obtained showed that enhanced sample/reagent mixing could be obtained with binary sampling and by using a 1 μL per step pump, even in limited dispersion conditions. Moreover, syringe pumps produce very reproducible flowing streams and are easily manipulated and controlled by a computer program, which is greatly simplified since they are the only active manifold component. Linear calibration plots up to 18.0 μg mL-1, with a relative standard deviation of less than 1.48% (n=10) and a throughput of about 20 samples per hour, were obtained.


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