TITLE

Gramicidin A interaction at a dioleoyl phosphatidylcholine monolayer on a mercury drop electrode

AUTHOR(S)
Lindholm-Sethson, Britta; Nyström, Josefina; Geladi, Paul; Nelson, Andrew
PUB. DATE
February 2003
SOURCE
Analytical & Bioanalytical Chemistry;Feb2003, Vol. 375 Issue 3, p350
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A biosensor where the sensing surface is a fluid dioleyl phosphatidylcholine monolayer (DOPC) deposited on a mercury drop was used. The lipid monolayer was held in 0.1 M NaCl and a concentration of gramicidin A in the range 0–12 nM was used. Electrochemical impedance spectroscopy in the frequency range 0.1–65 kHz was employed to investigate how the defect-free monolayer responds to interactions of gramicidin A in solution. The data was analyzed both with multivariate data analysis and classical electrochemical methods. The principal component analysis of the resulting impedance spectra gave a linear dependence on the concentration of gramicidin A. An increasing permittivity was observed in the low-frequency regime with increasing concentration of gramicidin A in solution.
ACCESSION #
15125523

 

Related Articles

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics