Effect of Cu(II) on the electrochemically initiated reaction of thiols with N,N-diethyl-p-phenylenediamine: methodology for the indirect voltammetric determination of Cu(II)

Kershaw, Jessica A.; Nekrassova, Olga; Banks, Craig E.; Lawrence, Nathan S.; Compton, Richard G.
June 2004
Analytical & Bioanalytical Chemistry;Jun2004, Vol. 379 Issue 4, p707
Academic Journal
The effect of Cu(II) on the determination of homocysteine via its electrochemically initiated reaction with N,N-diethyl-p-phenylenediamine is examined. The presence of copper inhibited the detection process for homocysteine owing to a complexation reaction occurring. This provided an indirect route for the sensitive and selective determination of Cu(II), which produced a linear response over the range from 2.5 to 500 μM and a limit of detection of 2.5 μM. The detection pathway was examined in the presence of metallic and inorganic ions, with negligible interference observed.


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