TITLE

Investigation of metal-binding metallothioneins in the tissues of rats after oral intake of cinnabar

AUTHOR(S)
Zhi-Yong Huang; Jin-Can Shen; Zhi-Xia Zhuang; Xiao-Ru Wang; Frank S. C. Lee
PUB. DATE
June 2004
SOURCE
Analytical & Bioanalytical Chemistry;Jun2004, Vol. 379 Issue 3, p427
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The multi-metal-binding MT fractions in rat tissues after oral intake of cinnabar were characterized by hyphenated size-exclusion chromatography (SEC) and inductively coupled plasma mass spectrometry (ICP–MS). With the increase of both the feeding time and dosage of cinnabar the amounts of Hg-binding MT fractions in rat kidney of groups fed cinnabar increased significantly compared with the control group. Meanwhile, more Cu-binding MT were synthesized in the rat kidney, which confirmed the manipulating effect of MT in the homeostasis of Cu for detoxification of nephritic mercury. Although the Hg-binding MT fractions in rat liver of all cinnabar groups were almost independent of cinnabar dosage (2.5–5.0 g kg-1 bw) and feeding time (2–4 weeks), the amount was much higher than that of the control group. The amounts of Hg-MT in other rat tissues of the cinnabar groups and the control group were compared and their significance is discussed.
ACCESSION #
15125081

 

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