TITLE

NMR study of some diastereomeric nucleoside-3′-thiophosphate derivatives in solution

AUTHOR(S)
Gács-Baitz, Eszter; Kajtár-Peredy, Mária; Sági, Gyula
PUB. DATE
May 2004
SOURCE
Analytical & Bioanalytical Chemistry;May2004, Vol. 379 Issue 1, p56
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The conformational properties of diastereomeric P-modified nucleotides are reported as reflected by different NMR parameters. Some conformational trends can be rationalized by consideration of the 3J(C4′,P)and 3J(C2′,P) coupling values of the isomers and the nature of the substituent on the phosphorus. Configurational assessment of the phosphorus is inferred from NOE experiments. The effects of temperature, solvent and size of substituents are presented.
ACCESSION #
15125027

 

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