Molecular imprinting technology: a simple way of synthesizing biomimetic polymeric receptors

Martin-Esteban, Antonio
April 2004
Analytical & Bioanalytical Chemistry;Apr2004, Vol. 378 Issue 8, p1875
Academic Journal
The article presents information on molecular imprinting technology. For several years, antibodies, enzymes, and other biological receptors have been successfully used in different areas of chemistry, especially when high selectivity is required. Molecularly imprinted polymers are tailor-made macroporous materials with selective binding sites able to recognize a particular molecule. Their synthesis is based on the formation of defined (covalent or non-covalent) interactions between a template molecule and functional monomers during a polymerization process in the presence of a cross-linking agent. After polymerization the template molecule is removed, leaving cavities complementary in size and shape to the analyte which, theoretically, thus enable the polymer to rebind this molecule selectively.


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