Micro- and nanofluidics for DNA analysis

Tegenfeldt, Jonas O.; Prinz, Christelle; Han Cao; Huang, Richard L.; Austin, Robert H.; Chou, Stephen Y.; Cox, Edward C.; Sturm, James C.
April 2004
Analytical & Bioanalytical Chemistry;Apr2004, Vol. 378 Issue 7, p1678
Academic Journal
Miniaturization to the micrometer and nanometer scale opens up the possibility to probe biology on a length scale where fundamental biological processes take place, such as the epigenetic and genetic control of single cells. To study single cells the necessary devices need to be integrated on a single chip; and, to access the relevant length scales, the devices need to be designed with feature sizes of a few nanometers up to several micrometers. We will give a few examples from the literature and from our own research in the field of miniaturized chip-based devices for DNA analysis, including dielectrophoresis for purification of DNA, artificial gel structures for rapid DNA separation, and nanofluidic channels for direct visualization of single DNA molecules.


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