Miniaturization in analytical and bioanalytical chemistry

Nilsson, Staffan; Laurell, Thomas
April 2004
Analytical & Bioanalytical Chemistry;Apr2004, Vol. 378 Issue 7, p1676
Academic Journal
The article presents information on miniaturization in analytical and bioanalytical chemistry. Within the past decade the field of miniaturization in chemical analysis has dramatically increased, fuelled by experience of the small sample volumes in capillary gas chromatography and capillary electrophoresis. In some cases the unfavorable surface-to-volume ratios in miniaturization can generate problems. Among the drawbacks is the risk of analyte adsorption to walls and interfaces. Another problem is optical interference at the walls of the sample container hampering detection.


Related Articles

  • SHORT COURSES.  // LC-GC North America;Sep2004, Vol. 22 Issue 9, p949 

    Presents short courses related to chromatography. Comprehensive capillary gas chromatography; Hands-on techniques of gas chromatography; Practical capillary electrophoresis; Peptide and protein characterization with mass spectrometry; Mechanical behavior of polymers.

  • Investigation of the loading capacity of multicapillary chromatographic columns. Patrushev, Yu. V.; Nikolaeva, O. A.; Sidelnikov, V. N. // Journal of Analytical Chemistry;Nov2010, Vol. 65 Issue 11, p1129 

    It was shown by the comparison of multicapillary and single-capillary columns for gas-liquid chromatography that an approximately 100-fold larger sample could be injected into multicapillary columns without substantial loss in efficiency, because the injected sample volume, causing no...

  • The Possibilities and Limitations of Capillary Extraction (CEx): The Case Study of Polycyclic Aromatic Hydrocarbons (PAHs) in Clean-Water Samples. Nardi, Luigi // LC-GC North America;Jan2007, Vol. 25 Issue 1, p66 

    Capillary extraction (CEx) is used to study the solventless in-tube extraction of naphthalene, acenaphthene, phenanthrene, fluoranthene, chrysene, benzo(a)pyrene and coronene in aqueous samples prepared by analyte spiking into clean waters or, as an alternative, by using the generator-column...

  • Sulfotepp in diazinon and other organophosphorus pesticides. Turle, Richard; Levac, Barry // Bulletin of Environmental Contamination & Toxicology;May1987, Vol. 38 Issue 5, p793 

    The article discusses a study on the application of sulfotepp in organophosphorus pest control substances and diazinon. It states that a compacted gas chromatography column gas was changed through the utilization of low-cost readily useable equipment to take on silica capillary column. A table...

  • Polymicro Technologies, A subsidiary of Molex Incorpaorated.  // LC-GC North America;Dec2009 Supplement, Vol. 27, p63 

    The article profiles capillary tubes and optical fibers producer Polymicro Technologies LLC, a subsidiary of Molex Inc., located in Phoenix, Arizona. The company supports several chromatographic techniques including gas chromatography (GC), capillary electrophoresis (CE) and cytometry. It is...

  • Analytical Methods for Determination of Antiepileptic Drugs. Jabbaribar, Farnaz; Mortazavi, Seyed A.; Jouyban, Abolghasem // Current Pharmaceutical Analysis;Aug2009, Vol. 5 Issue 3, p277 

    High performance liquid chromatography (HPLC), gas chromatography (GC), capillary electrophoresis (CE) and a number of immunoassay methods have been extensively applied to the analysis of antiepileptic drugs (AEDs) since many years ago providing reliable and accurate results. In addition,...

  • Chromatographic Determination of Amino Acids in Foods. Peace, Robert W.; Gilani, G. Sarwar // Journal of AOAC International;May/Jun2005, Vol. 88 Issue 3, p877 

    Discusses the chromatographic determination of amino acids in foods. Conditions of hydrolysis; Cation-exchange chromatography; Liquid chromatography; Gas chromatography; Capillary electrophoresis.

  • DataApex.  // LC-GC North America;Dec2009 Supplement, Vol. 27, p27 

    The article profiles chromatography software provider DataApex, headquartered in Prague, Czech Republic. It is founded in 1991 and has a total workforce population of 27 from the U.S. and other countries. It supports chromatographic techniques including high performance liquid chromatography...

  • Gas Chromatography at the 26th International Symposium on Capillary Chromatography and Electrophoresis. Hinshaw, John // LC-GC Europe;Oct2003, Vol. 16 Issue 10, p692 

    Reports on the 2003 International Symposium on Capillary Chromatography and Electrophoresis held in Las Vegas, Nevada. Highlights of the symposium; Presentation of the Marcel Golay Award in Capillary Chromatography and other awards; Conference sessions; Gas-phase separations; Liquid-phase...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics