TITLE

The use of ICPMS for stable isotope tracer studies in humans: a review

AUTHOR(S)
Stürup, Stefan
PUB. DATE
January 2004
SOURCE
Analytical & Bioanalytical Chemistry;Jan2004, Vol. 378 Issue 2, p273
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The use of stable isotope tracers in human studies is a rapidly growing research field that benefits from the many new developments in inorganic mass spectrometric instrumentation and from the better availability of mass spectrometric techniques to nutritional scientists during the last three decades. Traditionally, thermal ionization mass spectrometry (TIMS) has been the preferred technique for these studies, but the development of new inductively coupled plasma mass spectrometric (ICPMS) techniques with better isotope-ratio measurement and interference-removal capabilities (e.g. single and multi-detector ICPMS and reaction/collision cell ICPMS) has enabled broader use of ICPMS for determination of stable isotope tracers in nutritional research. This review discusses the current and future use of ICPMS in stable isotope tracer studies in humans.
ACCESSION #
15124863

 

Related Articles

  • TIMS versus multicollector-ICP-MS: coexistence or struggle for survival? Walczyk, Thomas // Analytical & Bioanalytical Chemistry;Jan2004, Vol. 378 Issue 2, p229 

    The article discusses the significance of stable isotopes. When J.J. Thomson discovered the isotopic nature of neon in 1912 using a self-constructed mass spectrograph it was difficult to foresee what impact stable isotope analysis would have in the natural sciences over the following decades....

  • Ultratrace analysis and isotope ratio measurements of long-lived radioisotopes by resonance ionization mass spectrometry (RIMS). Trautmann, N.; Passler, G.; Wendt, K. D. A. // Analytical & Bioanalytical Chemistry;Jan2004, Vol. 378 Issue 2, p348 

    Resonance Ionization Mass Spectrometry (RIMS) is a sensitive and selective method for ultratrace analysis of long-lived radioisotopes and isotope ratio measurements. It provides extremely high isobaric suppression and good overall efficiency. The experimental limits of detection are as low as...

  • The need for new isotope reference materials. Vogl, Jochen; Rosner, Martin; Pritzkow, Wolfgang // Analytical & Bioanalytical Chemistry;Mar2013, Vol. 405 Issue 9, p2763 

    Isotope reference materials are needed to calibrate and validate analytical procedures used for the determination of isotope amount ratios, procedurally defined isotope ratios or so-called δ values. In contrast to the huge analytical progress in isotope ratio analytics, the production of...

  • The Role of Naturally Occurring Stable Isotopes in Mass Spectrometry, Part I: The Theory. Bluck, Les; Volmer, Dietrich A. // Spectroscopy;Oct2008, Vol. 23 Issue 10, p36 

    The article focuses on the significance of naturally occurring stable isotopes in mass spectrometry (MS). It presents how the effects can be exploited in quantitative experiments, structural elucidation studies and tracer methodologies. Experiment shows that these isotopes result in a cluster of...

  • Measuring Dissociation Rate Constants of Protein Complexes through Subunit Exchange: Experimental Design and Theoretical Modeling. Pan, Chongle // PLoS ONE;2011, Vol. 6 Issue 12, p1 

    Protein complexes are dynamic macromolecules that constantly dissociate into, and simultaneously are assembled from, free subunits. Dissociation rate constants, koff, provide structural and functional information on protein complexes. However, because all existing methods for measuring koff...

  • Mass Spectrometry-Based Approaches Toward Absolute Quantitative Proteomics. Kito, Keiji; Ito, Takashi // Current Genomics;Jul2008, Vol. 9 Issue 4, p263 

    Mass spectrometry has served as a major tool for the discipline of proteomics to catalogue proteins in an unprecedented scale. With chemical and metabolic techniques for stable isotope labeling developed over the past decade, it is now routinely used as a method for relative quantification to...

  • The Role of Naturally Occurring Stable Isotopes in Mass Spectrometry, Part III: Small Gas Molecule Calculations. Bluck, Les; Volmer, Dietrich A. // Spectroscopy;Sep2009, Vol. 24 Issue 9, p34 

    The article focuses on the role of stable isotopes in mass spectrometry and the process of calculating small gas molecule. It explains the determination of the isotopic composition of sample from a mass spectrometric measurement, and the methods of calculation as well as the unit used. It...

  • Overcoming spectral overlap in isotopic analysis via single- and multi-collector ICP–mass spectrometry. Vanhaecke, Frank; Luc Moens // Analytical & Bioanalytical Chemistry;Jan2004, Vol. 378 Issue 2, p232 

    For isotope ratio applications where an internal isotope ratio precision >0.05–0.1% relative standard deviation suffices, single-collector inductively coupled plasma mass spectrometry (ICPMS) is fit-for-purpose, but for detecting more subtle variations in the natural isotopic composition...

  • Penning-trap mass measurements on Mo with JYFLTRAP. Kankainen, A.; Kolhinen, V.; Elomaa, V.; Eronen, T.; Hakala, J.; Jokinen, A.; Saastamoinen, A.; Äystö, J. // European Physical Journal A -- Hadrons & Nuclei;Apr2012, Vol. 48 Issue 4, p1 

    Penning-trap measurements on stable Mo isotopes have been performed with relative accuracy of $\ensuremath 1\cdot 10^{-8}$ with the JYFLTRAP Penning-trap mass spectrometer by using Rb as a reference. The Mo isotopes have been found to be about 3keV more bound than given in the Atomic Mass...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics