TITLE

Current perspectives of 14C-isotope measurement in biomedical accelerator mass spectrometry

AUTHOR(S)
Lappin, Graham; Garner, R. Colin
PUB. DATE
January 2004
SOURCE
Analytical & Bioanalytical Chemistry;Jan2004, Vol. 378 Issue 2, p356
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Accelerator mass spectrometry (AMS) is an extremely sensitive nuclear physics technique developed in the mid-70’s for radiocarbon dating of historical artefacts. The technique centres round the use of a tandem Van de Graaff accelerator to generate the potential energy to permit separation of elemental isotopes at the single atom level. AMS was first used in the early 90’s for the analysis of biological samples containing enriched 14C for toxicology and cancer research. Since that time biomedical AMS has been used in the study of (1) metabolism of xenobiotics in animals and humans (2) pathways of drug metabolism (3) biomarkers (4) metabolism of endogenous molecules including vitamins (5) DNA and protein binding studies and (6) clinical diagnosis. A new drug development concept which relies on the ultrasensitivity of AMS known as human microdosing (Phase 0) is being used to obtain early human metabolism information of candidate drugs arising out of discovery. These various aspects of AMS are reviewed in this article and a perspective on future applications of AMS provided.
ACCESSION #
15124849

 

Related Articles

  • Utility of Mass Spectrometry for In-Vitro ADME Assays. Inhou Chu; Nomeir, Amin A. // Current Drug Metabolism;Jul2006, Vol. 7 Issue 5, p467 

    A balance between pharmacological activity, safety and drug metabolism and pharmacokinetics (DMPK) at-tributes determines the fate of a new chemical entity (NCE) in drug discovery. Because of the increased number of NCEsrequiring DMPK evaluation, several in vitro higher-throughput screens and...

  • Utility of Mass Spectrometry for Pharmaceutical Profiling Applications. Kerns, Edward H.; Li Di // Current Drug Metabolism;Jul2006, Vol. 7 Issue 5, p457 

    MS has great utility for pharmaceutical profiling, the measurement of physicochemical and metabolic proper-ties that are crucial to the discovery and development of new drug candidates. An evaluation of the capabilities of MS toimprove the speed, specificity, sensitivity and cost per compound of...

  • Formation of the [M- 1]+ Ions of Methylindoles in APCI Mass Spectrometry. Liu, David Q.; Mingjiang Sun // ISRN Spectroscopy;2012, p1 

    Indoles are common building blocks of new pharmacologically active chemical entities in drug discovery and development. Due to their poor ionization in electrospray ionization mass spectrometry, atmospheric pressure chemical ionization (APCI) is the method of choice for LC-MS analysis of simple...

  • Capture Compound Mass Spectrometry A Technology for the Investigation of Small Molecule Protein Interactions. Hubert Köster; Daniel P. Little; Peng Luan; Rolf Muller; Suhaib M. Siddiqi; Subramanian Marappan; Ping Yip // Assay & Drug Development Technologies;Jun2007, Vol. 5 Issue 3, p381 

    One of the major hurdles in the post-genomic era is to understand the function of genes and the interplay of many different cellular proteins. This is especially important for drug development. Capture compound mass spectrometry (CCMS) addresses this challenge by selectively reducing the...

  • Ab initio scaling of the second hyperpolarizabilities of carbon cages. Fanti, Marianna; Fowler, Patrick W. // Journal of Chemical Physics;10/1/1997, Vol. 107 Issue 13, p5072 

    Discusses ab initio scaling of the second hyperpolarizabilities of carbon cages. Sum over molecular orbitals scheme in an ab initio basis set; Carbon cages available in macroscopic quantities; Range of nuclearities; Proposed scaling laws that lead to different values for systems with large...

  • A palaeocoastline reconstruction for the Käsmu and Pärispea peninsulas (northern Estonia) over the last 4000 years. Grudzinska, Ieva; Saarse, Leili; Vassiljev, Jüri; Heinsalu, Atko; Veski, Siim // Estonian Journal of Earth Sciences;Dec2012, Vol. 61 Issue 4, p307 

    The marine-freshwater environmental transition, i.e. basin isolation from the Limnea Sea, has been identified in two short sediment cores with respect to their diatom composition, loss-on-ignition and magnetic susceptibility content. The isolation level of the basins was dated by accelerator...

  • Profiles in Practice Series: Metabolism Identification and Structural Characterization in Drug Discovery. Balogh, Michael P. // LC-GC Europe;Jun2005, Vol. 18 Issue 6, p330 

    In this initial instalment of "MS in Practice," a new series of columns is introduced that investigates various aspects of mass spectrometry (MS) from the perspective of some leading practitioners. Here, featured scientists Kathleen Cox and Timothy Baker discuss several MS technologies and...

  • Mass Spectrometry: Drug Discovery's Essential Tool. Kube, D.M. // Drug Discovery & Development;May2003, Vol. 6 Issue 5, p71 

    Discusses the importance of mass spectrometry in drug discovery and development. Role in identifying natural products with therapeutic potentials; Leapfrogging advances of proteomics and mass spectrometry; Variety of measurement techniques for every type of sample. INSET: Mass Measurement...

  • Early Discovery Drug Screening Using Mass Spectrometry. Siegel, Marshall M. // Current Topics in Medicinal Chemistry;Jan2002, Vol. 2 Issue 1, p13 

    Electrospray ionization (ESI) and matrix-assisted laser desorption / ionization (MALDI) mass spectrometric methods useful for early discovery drug screening are reviewed. All methods described involve studies of non-covalent complexes between biopolymer receptors and small molecule ligands...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics