TITLE

Quantifying selectivity: a statistical approach for chromatography

AUTHOR(S)
Kapeller, Rudolf
PUB. DATE
November 2003
SOURCE
Analytical & Bioanalytical Chemistry;Nov2003, Vol. 377 Issue 6, p1060
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A parameter for quantitative description of selectivity is defined. A model for quantification of selectivity based on a statistical approach is drawn up. Formulas for quantification of selectivity are derived, especially for chromatography. These are based on theoretical and�as far as needed�empirical functions (made evident by experimental data or numerical simulations) or at least worst-case assumptions. An example (GC�MS determination of atrazine in drinking water) shows how quantification of selectivity can be achieved in practice. The approach is intended to be used for validation purposes.
ACCESSION #
15124805

 

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