TITLE

A new approach for assessing early osteoarthritis in the rat

AUTHOR(S)
Roberts, M. J.; Adams, S. B.; Patel, N. A.; Stamper, D. L.; Westmore, M. S.; Martin, S. D.; Fujimoto, J. G.; Brezinski, M. E.
PUB. DATE
November 2003
SOURCE
Analytical & Bioanalytical Chemistry;Nov2003, Vol. 377 Issue 6, p1003
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Several animal models have been developed to investigate osteoarthritis and potential disease-modifying therapeutics. However, early disease data from these models are limited by the resolution of current imaging modalities. In this in-vitro study, an optical coherence tomography (OCT) system with an axial resolution of 15 �m was used to track sequential changes in osteoarthritic rat knees. Osteoarthritis was induced via transection of the medial collateral ligament and an artificial full thickness meniscal tear. Imaging occurred at one, two, and three weeks after surgery. OCT successfully detected early signs of osteoarthritic change, including alteration of the cartilage surface and disruption of the bone�cartilage interface. This study demonstrates that OCT, along with the induction of mechanical injury, provides an excellent model for monitoring the sequential changes of osteoarthritis.
ACCESSION #
15124803

 

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