A new approach for assessing early osteoarthritis in the rat

Roberts, M. J.; Adams, S. B.; Patel, N. A.; Stamper, D. L.; Westmore, M. S.; Martin, S. D.; Fujimoto, J. G.; Brezinski, M. E.
November 2003
Analytical & Bioanalytical Chemistry;Nov2003, Vol. 377 Issue 6, p1003
Academic Journal
Several animal models have been developed to investigate osteoarthritis and potential disease-modifying therapeutics. However, early disease data from these models are limited by the resolution of current imaging modalities. In this in-vitro study, an optical coherence tomography (OCT) system with an axial resolution of 15 �m was used to track sequential changes in osteoarthritic rat knees. Osteoarthritis was induced via transection of the medial collateral ligament and an artificial full thickness meniscal tear. Imaging occurred at one, two, and three weeks after surgery. OCT successfully detected early signs of osteoarthritic change, including alteration of the cartilage surface and disruption of the bone�cartilage interface. This study demonstrates that OCT, along with the induction of mechanical injury, provides an excellent model for monitoring the sequential changes of osteoarthritis.


Related Articles

  • Computed Tomography of Neuroblastic Tumors in Children. Faerber, Eric N.; Carter, Barbara L.; Sarno, Robert C.; Leonidas, John C. // Clinical Pediatrics;Jan1984, Vol. 23 Issue 1, p17 

    Computed tomography (CT) was performed in 16 children with neuroblastic tumors, CT aided significantly in the accurate preoperative delineation of tumor extent and in the demonstration of tumor features not visualized by conventional radiography. CT provided excellent postoperative follow-up,...

  • Non-Invasive Transcranial Brain Therapy Guided by CT Scans: an In Vivo Monkey Study. Marquet, F.; Pernot, M.; Aubry, J.-F.; Montaldo, G.; Tanter, M.; Boch, A.-L.; Kujas, M.; Seilhean, D.; Fink, M. // AIP Conference Proceedings;2007, Vol. 911 Issue 1, p554 

    Brain therapy using focused ultrasound remains very limited due to the strong aberrations induced by the skull. A minimally invasive technique using time-reversal was validated recently in-vivo on 20 sheeps. But such a technique requires a hydrophone at the focal point for the first step of the...

  • Three-dimensional computed tomography analysis of non-osteoarthritic adult acetabular dysplasia. Hiroshi Ito; Takeo Matsuno; Teruhisa Hirayama; Hiromasa Tanino; Yasuhiro Yamanaka; Akio Minami // Skeletal Radiology;Feb2009, Vol. 38 Issue 2, p131 

    Abstract Objective  Little data exists on the original morphology of acetabular dysplasia obtained from patients without radiographic advanced osteoarthritic changes. The aim of this study was to investigate the distribution and degree of acetabular dysplasia in a large number of...

  • Computed tomography and magnetic resonance imaging of desmoplastic fibroma with simultaneous manifestation in two unusual locations: a case report.  // Journal of Medical Case Reports;2011, Vol. 5 Issue 1, p1 

    The article presents a case study of a 56-year-old Caucasian man with a history of desmoplastic fibroma, and lumbar pain. After computed tomography and magnetic resonance imaging (MRI), it was revealed two lytic expansile lesions affecting both his left iliac bone and his left sacral wing. It...

  • Emergency percutaneous treatment in iatrogenic hepatic arterial injuries. Gianpaolo Carrafiello; Domenico Laganà; Massimiliano Dizonno; Elisa Cotta; Andrea Ianniello; Carlo Fugazzola // Emergency Radiology;Jul2008, Vol. 15 Issue 4, p249 

    Abstract  The purpose of this report is to present our experience in the emergency percutaneous treatment of patients with iatrogenic hepatic arterial injury (IHAI). Seven patients (six men, one woman; age range 19–78 years; mean age 63 years) with IHAI secondary to surgical...

  • [[sup18]F]Fluorodeoxyglucose Positron Emission Tomography Surveillance of Hepatic Metastases from Prostate Cancer Following Radiofrequency Ablation: A Case Report. Ludwig, Vinicius; Hopper, Orlin W.; Martin, William H.; Kikkawa, Rita; Delbeke, Dominique // American Surgeon;Jul2003, Vol. 69 Issue 7, p593 

    Presents a case study of the use of [[sup18]F]Fluorodeoxyglucose positron emission tomography to monitor therapy of hepatic metastases after radiofrequency ablation (RFA). Principle behind RFA; Clinical course of the patient; Discussion.

  • Holmium-166 poly( L-lactic acid) microsphere radioembolisation of the liver: technical aspects studied in a large animal model. Vente, M. A. D.; de Wit, T. C.; van den Bosch, M. A. A. J.; Bult, W.; Seevinck, P. R.; Zonnenberg, B. A.; de Jong, H. W. A. M.; Krijger, G. C.; Bakker, C. J. G.; van het Schip, A. D.; Nijsen, J. F. W. // European Radiology;Apr2010, Vol. 20 Issue 4, p862 

    To assess the accuracy of a scout dose of holmium-166 poly( L-lactic acid) microspheres (166Ho-PLLA-MS) in predicting the distribution of a treatment dose of 166Ho-PLLA-MS, using single photon emission tomography (SPECT). A scout dose (60 mg) was injected into the hepatic artery of five pigs and...

  • Value of 18F-FDG PET in the detection of peritoneal carcinomatosis. Suzuki, Akiko; Kawano, Tsuyoshi; Takahashi, Nobukazu; Jin Lee; Nakagami, Yoshihiro; Miyagi, Etsuko; Hirahara, Fumiki; Toga, Shinji; Shimada, Hiroshi; Inoue, Tomio // European Journal of Nuclear Medicine & Molecular Imaging;2004, Vol. 31 Issue 10, p1413 

    Purpose: Peritoneal carcinomatosis can he difficult to diagnose using computed tomography (CT). The purpose of this study was to evaluate the role of 2-(fluorine 18) fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) in the detection of peritoneal carcinomatosis Methods: We...

  • Transcatheter arterial embolization in the management of hemobilia. Srivastava, Deep; Sharma, S.; Pal, S.; Thulkar, S.; Seith, A.; Bandhu, S.; Pande, G.; Sahni, P. // Abdominal Imaging;Jul2006, Vol. 31 Issue 4, p439 

    This retrospective analysis evaluated the clinical and radiologic results of transcatheter arterial embolization (TAE) in the treatment of significant hemobilia. The imaging findings, embolization technique, complications, and efficacy are described. Thirty-two consecutive patients (21 male, 11...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics