TITLE

Protease sensors for bioimaging

AUTHOR(S)
Funovics, Martin; Weissleder, Ralph; Ching-Hsuan Tung
PUB. DATE
November 2003
SOURCE
Analytical & Bioanalytical Chemistry;Nov2003, Vol. 377 Issue 6, p956
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Optical imaging of specific molecular targets and pathways in vivo has recently become possible through continued developments in imaging equipment, reconstruction algorithms, and more importantly the availability of imaging reporter molecules. These reporter molecules encompass photoproteins expressed in vivo and exogenously administered probes detectable by fluorescence and/or bioluminescence imaging. One particularly enticing aspect of optical imaging is the ability to design activatible probes with inherent amplification. This review summarizes our experience in developing novel near-infrared fluorescent (NIRF) imaging agents that report on protease activities. These agents are designed to be biocompatible, highly activatible, and able to produce bright NIRF following protease cleavage.
ACCESSION #
15124788

 

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