A validated spectrofluorometric method for the determination of celecoxib in capsules

Damiani, Patricia; Bearzotti, Mariela; Cabezón, Miguel A.
August 2003
Analytical & Bioanalytical Chemistry;Aug2003, Vol. 376 Issue 7, p1141
Academic Journal
A rapid, selective, sensitive and simple fluorescence method was developed for the direct determination of celecoxib in capsules. The capsules were emptied, pulverized and dissolved in either ethanol or acetonitrile, sonicated and filtered. Direct fluorescence emission was measured at 355±5 nm (exciting at 272 nm). The method was fully validated and the recoveries were excellent, even in presence of excipients.


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