Single-cell analysis by capillary electrophoresis

Stuart, Jeffrey N.; Sweedler, Jonathan V.
January 2003
Analytical & Bioanalytical Chemistry;Jan2003, Vol. 375 Issue 1, p28
Academic Journal
The article focuses on single-cell analysis by capillary electrophoresis (CE). It informs that on a more diminutive scale, from cellular cluster to single cell to sub-cellular compartment, the demands placed on analytical instrumentation are amplified, and perhaps no recent technique has greater potential for this application than single cell CE. Since the first assay of a single neuron from Helix aspersa by capillary liquid chromatography and CE, many advances in microscale separations have been realized that improve the information obtained from single-cell assays. While chemical analysis of single cells has a long history, the range of cells and the number of chemical constituents that can be measured is rapidly growing.


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