TITLE

Influence of pericardial suction blood retransfusion on memory function and release of protein S100B

AUTHOR(S)
Svenmarker, S.; Engström, K.G.; Karlsson, T.; Jansson, E.; Lindholm, R.; Åberg, T.
PUB. DATE
November 2004
SOURCE
Perfusion;Nov2004, Vol. 19 Issue 6, p337
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: To study the influence of pericardial suction blood (PSB) on postoperative memory disturbances and release patterns of protein S100B during and after cardiopulmonary bypass (CPB). Methods: Sixty male patients admitted for coronary artery bypass surgery were prospectively randomized to receive PSB either by using conventional cardiotomy suction retransfusion or after cell-saver processing. Results: The concentration of S100B rose during the period of CPB from 0.065 ± 0.004 to 0.24 ± 0.001m g/L (p < 0.001). PSB contained 18.0 ± 1.7m g/L of S100B. Direct retransfusion from the cardiotomy reservoir made the systemic level increase to 1.42 ± 0.19 m g/L compared to 0.25 ± 0.02 m g/L using a cell-saver. Signs of postoperative memory dysfunction (> 1 SD) were discovered in one of three tests, but were unrelated to technique of retransfusion. No associations were found between serum concentrations of S100B and memory function. Conclusion: In this study, retransfusion of PSB during cardiac surgery appeared not to cause memory disturbances. PSB contained high concentrations of protein S100B making its use as a marker of cerebral injury unsuitable.
ACCESSION #
15124100

 

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