TITLE

Anal Condyloma: A Comparison Between HIV Positive and Negative Patients

AUTHOR(S)
Anderson, C. A.; Boller, A. M.; Richardson, C. J.; Balcos, E. G.; Zera, R. T.
PUB. DATE
November 2004
SOURCE
American Surgeon;Nov2004, Vol. 70 Issue 11, p1014
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
HIV positive and negative patients with anal condylomata were compared to determine an association with squamous cell neoplasia, its disease progression, and response to treatment. From 1992 to 2003, 61 patients were diagnosed with anal condylomata by anal biopsy. Thirty-four patients were HIV+ and 27 patients were considered HIV-. Upon retrospective chart review, details on disease progression, development of malignancy, and subsequent treatment were collected. Sixty-one per cent of HIV+ patients had a neoplastic process in contrast to 25 per cent HIV- patients (P = 0.005). Five patients demonstrated disease progression, of which four were HIV-H. Three HIV-H patients were treated for invasive carcinoma with excision and standard chemoradiation therapy. Two patients with T3 lesions developed recurrence and died. Eighteen HIVH- patients had noninvasive carcinoma and were treated with local excision without recurrence at mean follow-up of 28 months. HIV+ patients were shown to have more condylomata harboring squamous cell neoplasia than HIV- patients. Noninvasive carcinoma can be treated effectively with local excision, independent of HIV status; however, long-term follow-up is needed. Chemoradiation therapy in patients who are relatively healthy and have stage I disease may successful. The role for chemoradiation in AIDS patients with stage III disease remains unclear.
ACCESSION #
15109343

 

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