TITLE

Use of Yttrium-90 TheraSphere for the Treatment of Unresectable Hepatocellular Carcinoma

AUTHOR(S)
Liu, Michael D.; Uaje, Michelle B.; Al-Ghazi, Muthana S.; Fields, Denise; Herman, June; Kuo, Jeffrey V.; Milne, Norah; Nguyen, Thong H.; Ramsinghani, Nilam S.; Tokita, Kenneth M.; Tsai, Fong Y.; Vajgrt, Duane J.; Imagawa, David K.
PUB. DATE
November 2004
SOURCE
American Surgeon;Nov2004, Vol. 70 Issue 11, p947
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This is a retrospective analysis of a new treatment modality, intra-arterial administration of Yttrium-90 TheraSphere, for unresectable hepatocellular carcinoma (HCC). Patients with HCC not amenable to surgical treatment who had satisfactory physiological function without comorbid disease or significant pulmonary shunting were eligible for treatment. Patients were categorized into complete, partial, or no response based on serum alpha-fetoprotein (AFP) levels and CT or MRI imaging. Fourteen patients were considered candidates for treatment. Three patients were excluded due to significant hepatopulmonary shunting. Eleven patients were treated with Thera-Sphere. One patient (9%) had a complete response, eight patients (78%) had a partial response, and two patients (18%) showed no response. Partial and complete responders with AFP-associated HCC demonstrated a median decrease in AFP levels of 79 per cent at 73 days. No patients developed liver toxicity nor died due to treatment. Five patients (45%) died of progressive disease at a median of 7 months post-treatment. Six patients (54%) were alive at a median of 11 months (range, 9 to 20 months). Okuda stage 2 and 3 patients showed a median survival of 11 months and 7 months, respectively. Yttrium-90 TheraSphere treatment for unresectable hepatocellular carcinoma is well tolerated and appears to extend survival.
ACCESSION #
15109156

 

Related Articles

  • Complications of radiofrequency ablation in hepatocellular carcinoma. Rhim, H. // Abdominal Imaging;Jul/Aug2005, Vol. 30 Issue 4, p409 

    Radiofrequency thermal ablation has been accepted as a promising technique to treat unresectable liver tumors. However, any interventional procedure should be performed only if the procedure is safe, with minimal morbidity and mortality rates. Recently, three separate multicenter surveys have...

  • Percutaneous image-guided radiofrequency ablation in the therapeutic management of hepatocellular carcinoma. Lencioni, R.; Della Pina, C.; Bartolozzi, C. // Abdominal Imaging;Jul/Aug2005, Vol. 30 Issue 4, p401 

    Owing to surveillance programs for detection of hepatocellular carcinoma (HCC) in patients with cirrhosis, more tumors are being detected at an early, asymptomatic stage. Percutaneous ablation is considered the best treatment option for patients with Child-Pugh class A or B cirrhosis and a...

  • Treatment of Hypervascular Small Hepatocellular Carcinoma with Ultrasound-Guided Percutaneous Acetic Acid Injection: Comparison with Segmental Transcatheter Arterial Embolization. Ohnishi, Kunihiko; Yoshioka, Hisashi; Kosaka, Kenichi; Toshima, Kenichi; Nishiyama, Junichi; Kameda, Chisato; Ito, Susumu; Fujiwara, Kenji // American Journal of Gastroenterology;Dec1996, Vol. 91 Issue 12, p2574 

    Objective: To compare the efficacy of ultrasound-guided percutaneous acetic acid injection and segmental transcatheter arterial embolization for hypervascular small hepatocellular carcinoma. Methods: The prognosis of 40 patients with one to three angiographically hyper-vascular hepatocellular...

  • Tumor Size Does Not Independently Affect Long-Term Survival after Curative Resection of Solitary Hepatocellular Carcinoma Without Macroscopic Vascular Invasion. Zhang, Han; Yuan, Shou-Xin; Dai, Shu-Yang; Zhang, Jin-Min; Huang, Xing; Lu, Chong-De; Lu, Jun-Hua; Wu, Fu-Quan; Lau, Wan; Wu, Meng-Chao; Yang, Tian; Shen, Feng // World Journal of Surgery;Apr2014, Vol. 38 Issue 4, p947 

    Objective: The aim of this study was to investigate the prognostic value of tumor size alone on long-term survival and recurrence after curative resection for solitary hepatocellular carcinoma (HCC) without macroscopic vascular invasion. Methods: A single-center cohort of 615 patients with...

  • Methodological Aspects and Applications of In Vivo Imaging of Apoptosis in Oncology: An Illustrative Review. Kartachova, Marina S.; Verheij, Marcel; Hoefnagel, Cornelis A.; Van Eck, Berthe L.; Olmos, Renato A. Vald�s // Current Medical Imaging Reviews;2005, Vol. 1 Issue 3, p221 

    In vivo monitoring of apoptosis during anticancer therapy has attracted intense research interest as a potential assay to predict treatment outcome. From all apoptosis-detecting radioligands, the group of Annexin V-based tracers is currently the most widely used for real time imaging of...

  • Seeing into cells. Sullivan, Daniel C.; Kelloff, Gary // EMBO Reports;Apr2005, Vol. 6 Issue 4, p292 

    This article focuses on the use of in vivo molecular imaging in oncology. Medicine is undergoing a revolution. Disease is increasingly being redefined in terms of underlying molecular abnormalities, as opposed to the signs and symptoms of the patient. This new definition is referred to as the...

  • Subpleural lung tumors ultrasonography. Rednic, Nicolae; Orăşan, Olga; Orasan, Olga // Medical Ultrasonography;Mar2010, Vol. 12 Issue 1, p81 

    The assessment of patients with pulmonary focal abnormalities continues to represent an important problem in pulmonary diagnosis. A large number of lung nodules remains undetermined after bronchoscopy, radiological and CT imaging analysis. Ultrasound can contribute to the determination of the...

  • Hepatocellular carcinoma treated with transarterial chemoembolization: Dynamic perfusion-CT in the assessment of residual tumor. Ippolito, Davide; Bonaffini, Pietro Andrea; Ratti, Laura; Antolini, Laura; Corso, Rocco; Fazio, Ferruccio; Sironi, Sandro // Annals of Gastroenterology & Hepatology;2011, Vol. 9 Issue 94, p5993 

    AIM: To asses the value of computed tomography (CT)-perfusion in the detection of residual hepatocellular carcinoma (HCC) vascularization after transarterial chemoembolization (TACE). METHODS: Thirty-two consecutive patients were prospectively included in this study. All patients had liver...

  • Hepatic Abscess with Biliary Communication Following Transarterial Chemoembolization of Hepatocellular Carcinoma. Huang, Robert; Ambrosy, Andrew; Triadafilopoulos, George // Digestive Diseases & Sciences;Sep2013, Vol. 58 Issue 9, p2463 

    No abstract available.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics