TITLE

Rosuvastatin and Asian subjects

PUB. DATE

August 2004

SOURCE

WHO Drug Information;2004, Vol. 18 Issue 3, p223

SOURCE TYPE

Academic Journal

DOC. TYPE

Article

ABSTRACT

The article reports that the manufacturer of rosuvastatin has submitted a labelling amendment to indicate information on a twofold increase in median AUC after a single dose of rosuvastatin given to Chinese patients in Singapore compared to western Caucasian patients. Pharmacokinetic studies show an approximately two-fold elevation in median AUC comparing western Caucasians and Japanese subjects residing in Japan. Rosuvastatin should be prescribed with caution in patients with predisposing factors for myopathy, or situations where an increase in plasma levels may occur.

ACCESSION #

15085611

Tags: DRUGS -- Labeling;  CAUCASIAN race;  PHARMACOKINETICS;  MUSCLES -- Diseases

 

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