Rosuvastatin and Asian subjects
- The investigation of allele and genotype frequencies of CYP3A5 (1*/3*) and P2Y12 (T744C) in Iran. Azarpira, N.; Namazi, S.; Khalili, A.; Tabesh, M. // Molecular Biology Reports;Nov2011, Vol. 38 Issue 8, p4873
Research on the frequency of the highly functional mutations of genes coding required for metabolizing enzymes has shown significant ethnic variations. However, few studies, if any, have examined the frequency distribution of major allelic variations in the context of Iran. In this regard, the...
- Prolonged Toxicity after Amitriptyline Overdose in a Patient Deficient in CYP2D6 Activity. Smith, Jennifer Cohen; Curry, Steven C. // Journal of Medical Toxicology;Sep2011, Vol. 7 Issue 3, p220
Introduction: Amitriptyline and its metabolite, nortriptyline, are metabolized, in part, by CYP2D6, a polymorphic enzyme. About 8% of Caucasians are deficient in CYP2D6 activity. Case Report: We present the case of a comatose woman who intentionally overdosed on amitriptyline and displayed...
- Mutations in the mitochondrial tRNASer(AGY) gene are associated with deafness, retinal degeneration, myopathy and epilepsy. Tuppen, Helen AL; Naess, Karin; Kennaway, Nancy G; Al-Dosary, Mazhor; Lesko, Nicole; Yarham, John W; Bruhn, Helene; Wibom, Rolf; Nennesmo, Inger; Weleber, Richard G; Blakely, Emma L; Taylor, Robert W; McFarland, Robert // European Journal of Human Genetics;Aug2012, Vol. 20 Issue 8, p897
Although over 200 pathogenic mitochondrial DNA (mtDNA) mutations have been reported to date, determining the genetic aetiology of many cases of mitochondrial disease is still not straightforward. Here, we describe the investigations undertaken to uncover the underlying molecular defect(s) in two...
- The pharmacokinetics and pharmacodynamics of prasugrel in healthy Chinese, Japanese, and Korean subjects compared with healthy Caucasian subjects. Small, David; Kothare, Prajakti; Yuen, Eunice; Lachno, D.; Li, Ying; Winters, Kenneth; Farid, Nagy; Ni, Lan; Jakubowski, Joseph; Salazar, Daniel; Thieu, Vivian; Payne, Christopher // European Journal of Clinical Pharmacology;Feb2010, Vol. 66 Issue 2, p127
Prasugrel is a novel thienopyridine prodrug metabolised to an active metabolite that binds irreversibly to the platelet P2Y12 receptor and inhibits adenosine diphosphate (ADP)-induced platelet aggregation. We compared prasugrel pharmacokinetics, pharmacodynamics, and tolerability in healthy...
- Pharmacokinetics and 48 week efficacy of low-dose lopinavir/ritonavir in HIV-infected children. Puthanakit, Thanyawee; Van der Lugt, Jasper; Bunupuradah, Torsak; Ananworanich, Jintanat; Gorowara, Meena; Phasomsap, Chayapa; Jupimai, Thidarat; Boonrak, Pitch; Pancharoen, Chitsanu; Burger, David; Ruxrungtham, Kiat // Journal of Antimicrobial Chemotherapy (JAC);Nov2009, Vol. 64 Issue 5, p1080
Background: Lopinavir/ritonavir is a common protease inhibitor (PI) used for second-line regimens in children. Several studies have shown higher plasma concentrations of antiretroviral agents in Thai adults than in Caucasians, suggesting that lower doses may be used.
- Association study of genetic polymorphisms of drug transporters, SLCO1B1, SLCO1B3 and ABCC2, in African-Americans, Hispanics and Caucasians and olmesartan exposure. Endo, Seiko; Fukahori, Aiko; Tokuhiro, Shinya; Shinagawa, Akira; Walker, Joseph; Yoshihara, Kazutaka; Ishizuka, Hitoshi; Ieiri, Ichiro; Sugiyama, Yuichi // Journal of Human Genetics;Aug2012, Vol. 57 Issue 8, p531
It has been reported that organic anion-transporting polypeptide (OATP) 1B1, OATP1B3 and multidrug resistance-associated protein 2 are involved in the hepatobiliary transport of olmesartan. We investigated the association of SLCO1B1, SLCO1B3 and ABCC2 polymorphisms with the pharmacokinetics of...
- Steady-State Carbamazepine Pharmacokinetics Following Oral and Stable-Labeled Intravenous Administration in Epilepsy Patients: Effects of Race and Sex. Marino, S E; Birnbaum, A K; Leppik, I E; Conway, J M; Musib, L C; Brundage, R C; Ramsay, R E; Pennell, P B; White, J R; Gross, C R; Rarick, J O; Mishra, U; Cloyd, J C // Clinical Pharmacology & Therapeutics;Mar2012, Vol. 91 Issue 3, p483
Carbamazepine is a widely prescribed antiepileptic drug. Owing to the lack of an intravenous formulation, its absolute bioavailability, absolute clearance, and half-life in patients at steady state have not been determined. We developed an intravenous, stable-labeled (SL) formulation in order to...
- metaxalone. // Davis's Drug Guide for Nurses, 9th edition;2005, p659
Provides information on metaxalone, a skeletal muscle relaxant used for the treatment of muscle spasm. Pharmacokinetics; Contraindications and precautions; Adverse reactions and side effects; Prescribed dosage.
- methocarbamol. // Davis's Drug Guide for Nurses, 9th edition;2005, p666
Provides information on methocarbamol, a skeletal muscle relaxant used for the adjunctive treatment of muscle spasm. Pharmacokinetics; Contraindications and precautions; Adverse reactions and side effects; Prescribed dosage.