Hidden IgA subclass determinants in human renal disease

Melvin, Tyrone R.; Youngki Kim; Conley, Mary Ellen; Delacroix, Dominique L.; Michael, Alfred F.
April 1985
Kidney International;Apr1985, Vol. 27 Issue 4, p685
Academic Journal
Presents the study on the role of immunoglobulin A as subclass determinant in human renal disease. Use of monoclonal antibodies; Detection of glomerular immune deposits in human renal diseases; Evidence of systematic disease.


Related Articles

  • Evidence-based classification of glomerular pathology. Cook, Terry; Roberts, Ian S D; Feehally, John; Barratt, Jonathan // Kidney International;Nov2014, Vol. 86 Issue 5, p1059 

    A letter to the editor is presented in response to an article about the Oxford Classification of IgA Nephropathy as evidence-based classification of glomerular disease.

  • monoclonal antibody.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1486 

    An encyclopedia entry for "monoclonal antibody," which refers to the antibody which is specific to a certain antigen, is presented.

  • Induction of microhematuria by an IgA isotype switch variant of a monoclonal anti-Thy-1.1 antibody in the rat. Van Dixhoorn, Mieneke G. A.; Gorter, Arko; Sato, Toshinobu; Van Der Wal, Annemieke M.; Jaap D. H. Van Eendenburg; Rozing, Jan; Daha, Mohamed R.; De Heer, Emile // Kidney International;Nov1996, Vol. 50 Issue 5, p1612 

    IgA nephropathy (IgAN) is a chronic form of glomerulonephritis (GN) characterized by the deposition in the glomerular mesangium of mainly IgA. An experimental form of mesangial proliferative GN can be induced in rats by either polyclonal or monoclonal antibodies against Thy-1.1, a glycoprotein...

  • Serum IgA1 from IgA nephropathy patients induces apoptosis in podocytes through direct and indirect pathways. Cheng Wang; Hui Peng; Hua Tang; Xun Liu; Zhujiang Chen; Tanqi Lou; Xueqing Yu // Clinical & Investigative Medicine;Dec2007, Vol. 30 Issue 6, pE240 

    Purpose: To investigate apoptosis of podocytes induced by IgA1 isolated from IgA nephropathy (IgAN) patients through direct and indirect pathways. Methods: Jacalin affinity chromatography and Sephacryl S-200 molecular sieve chromatography were used to isolate IgA1 from blood of IgAN patients...

  • IgA nephropathy.  // Kidney International;Feb1995, Vol. 47 Issue 2, p377 

    The article profides information on various topics related immunoglobulin A nephropathy (IgAN). The main function of the IgA system is to prevent the invasion of the internal milieu. IgAN presents with painless macroscopic hematuria frequently at the time of infectious illnesses. Moreover, the...

  • Steroids in the Treatment of IgA Nephropathy to the Improvement of Renal Survival: A Systematic Review and Meta-Analysis. Yu-Hao Zhou; Li-Gong Tang; Shi-Lei Guo; Zhi-Chao Jin; Mei-Jing Wu; Jia-Jie Zang; Jin-Fang Xu; Chun-Fang Wu; Ying-Yi Qin; Qing Cai; Qing-Bin Gao; Shan-Shan Zhang; Dand-Hui Yu; Jia He // PLoS Clinical Trials;Apr2011, Vol. 8 Issue 4, Special section p1 

    Background: Studies have shown that steroids can improve kidney survival and decrease the risk of proteinuria in patients with Immunoglobulin A nephropathy, but the overall benefit of steroids in the treatment of Immunoglobulin A nephropathy remains controversial. The aim of this study was to...

  • Nutcracker phenomenon in IgA nephropathy. Imai, Naohiko; Shirai, Sayuri; Shibagaki, Yugo; Kimura, Kenjiro // Clinical Kidney Journal;Jun2014, Vol. 7 Issue 3, p325 

    The article presents a case study of a 34-year-old Japanese woman with recurrent gross hematuria. Her medical history was unremarkable and was not taking any medications. Topics include hematuria and proteinuria, nutcracker phenomenon in IgA nephropathy and percutaneous kidney biopsy. It also...

  • Persistent microhaematuria with negative or low proteinuria. GutiĆ©rrez, Eduardo; Moreno, Juan A.; Praga, Manuel // Nefrologia;2014, Vol. 34 Issue 1, p110 

    The level of proteinuria continues to be the clinical parameter that is best related to the development of long-term renal failure in glomerular pathologies. This quantity is particularly important when we analyse the progression of patients with IgA nephropathy. As such, the natural progression...

  • Strong association between IgA nephropathy and HLA-DR4 antigen. Kashiwabara, Hidehiko; Shishido, Hideo; Tomura, Shigeo; Tuchida, Hiroki; Miyajima, Tetsuya // Kidney International;Oct1982, Vol. 22 Issue 4, p377 

    Although the etiology and pathogenesis of IgA nephropathy is not fully understood, it has been classified as an immune-complex induced glomerulonephritis caused by an immunological mechanism. Forty-two patients with primary IgA nephropathy underwent tissue typing for HLA-A, B, and DR antigens by...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics