Measurement of residual glomerular filtration rate in the patient receiving repetitive hemodialysis

Milutinovic, Jovan; Cutler, Ralph E.; Hoover, Patricia; Meijsen, Barbara; Scribner, Belding H.
September 1975
Kidney International;Sep1975, Vol. 8 Issue 3, p185
Academic Journal
The objective of the current study was to determine the best index of residual glomerular filtration rate (GFR) by comparing simultaneously measured clearances of inulin, 125I-iothalamate, endogenous creatinine, urea and 169ytterbium diethylenetriaminepentaacetic acid (169YB-DTPA) in patients receiving repetitive hemodialysis. In patients with GFR <5 ml/min but > 1 ml/min, 125I-iothalamate clearance showed the best correlation with inulin clearance. However, creatinine clearance correlated better with inulin clearance than urea clearance and as well was urea + creatinine/2. In the patients with measured GFR <1 ml/min, the correlation of 125I-iothalamate, creatinine, urea and urea + creatinine/two clearances with inulin clearance was satisfactory. Similarly, satisfactory correlations were obtained when the relationships were examined across the entire range of measured clearances <5 ml/min. A simple, practical method is described for the accurate serial measurement of residual GFR in patients receiving repetitive dialysis.


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