Renal function before and after unilateral nephrectomy in renal donors

Pabico, Rufino C.; McKenna, Barbara A.; Freeman, Richard B.
September 1975
Kidney International;Sep1975, Vol. 8 Issue 3, p166
Academic Journal
Measurements of glomerular filtration rate (GFR), effective renal plasma flow-(ERPF), tubular maximum reabsorption of glucose (Tmglucose) and secretion of para-aminohippurate (TmPAH), clearance of inorganic phosphate (Cphosphate) and uric acid (Curic acid), urine diluting capacity (CH2O) and urinary net acid excretion (UH + V) were made before and 10 to 14 days after unilateral nephrectomy in seven healthy, renal donors. Comparisons were made between the functions of the remaining kidney and 50% of pre-uninephrectomy values. Mean post-uninephrectomy GFR increased by 37%, and mean ERPF, 55%. Tmglucose, TmPAH, Cphospate, Curic acid, CH2O, uninephrectomy. The increase in TmPAH, Tmglucose and CH2O is proportional to the rise in GFR while the increase in Cphosphate, Curic acid and UH + V is proportionally greater than the increase in GFR. The changes in post-uninephrectomy renal handling of phosphate are not due to an increase in parathyroid hormone secretion.


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