Influence of ethacrynic acid on intrarenal renin release mechanisms

Eide, Ivar; Løyning, Einar; Langård, Øivind; Kiil, Fredrik
September 1975
Kidney International;Sep1975, Vol. 8 Issue 3, p158
Academic Journal
Ethacrynic acid infused i.v. in anesthetized dogs after inhibiting sympathetic mechanisms of renin release increased renal blood flow rate (RBF) by 54% and practically abolished autoregulation of RBF; renin release increased from 0.8 &plusm; 0.9 (mean &plusm; SEM) to 16.4 &plusm; 3.7 μg/min (P ≤ 0.05). Without infusion of ethacrynic acid; constriction of the renal artery to a pressure below, the range of autoregulation reduced renovascular resistance markedly and renin release rose to 27.2 &plusm; 5.5 μg/min (P ≤ 0.05). During arterial constriction, ethacrynic acid had no additional effect on renovascular resistance or renin release averaging 28.4 &plusm; 6.7 μg/min. Infusion of ethacrynic acid and saline at control pressure increased sodium excretion to about one-half of the filtrate and reduced renin release which did not, however, return to control. Infusion of hypertonic saline during autoregulated vasodilatation induced by arterial constriction had a similar effect, but again renin release continued to exceed control. We propose that ethacrynic acid increases renin release through a hemodynamic mechanism triggered by afferent arteriolar dilatation and inhibits renin release by greatly increasing the delivery of sodium to the distal convoluted tubules.


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