TITLE

Influence of ethacrynic acid on intrarenal renin release mechanisms

AUTHOR(S)
Eide, Ivar; Løyning, Einar; Langård, Øivind; Kiil, Fredrik
PUB. DATE
September 1975
SOURCE
Kidney International;Sep1975, Vol. 8 Issue 3, p158
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Ethacrynic acid infused i.v. in anesthetized dogs after inhibiting sympathetic mechanisms of renin release increased renal blood flow rate (RBF) by 54% and practically abolished autoregulation of RBF; renin release increased from 0.8 &plusm; 0.9 (mean &plusm; SEM) to 16.4 &plusm; 3.7 μg/min (P ≤ 0.05). Without infusion of ethacrynic acid; constriction of the renal artery to a pressure below, the range of autoregulation reduced renovascular resistance markedly and renin release rose to 27.2 &plusm; 5.5 μg/min (P ≤ 0.05). During arterial constriction, ethacrynic acid had no additional effect on renovascular resistance or renin release averaging 28.4 &plusm; 6.7 μg/min. Infusion of ethacrynic acid and saline at control pressure increased sodium excretion to about one-half of the filtrate and reduced renin release which did not, however, return to control. Infusion of hypertonic saline during autoregulated vasodilatation induced by arterial constriction had a similar effect, but again renin release continued to exceed control. We propose that ethacrynic acid increases renin release through a hemodynamic mechanism triggered by afferent arteriolar dilatation and inhibits renin release by greatly increasing the delivery of sodium to the distal convoluted tubules.
ACCESSION #
15027480

 

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