Effects of jaundiced plasma on vascular sensitivity to noradrenalin

Bloom, David; McCalden, Thomas A.; Rosendorff, Clive
September 1975
Kidney International;Sep1975, Vol. 8 Issue 3, p149
Academic Journal
Alterations in renal perfusion have been shown in a variety of liver diseases. We have examined the possibility that the syndrome is due to u renal vascular hypersensitivity to noradrenalin (NA). Isolated perfused kidneys and segments of rabbit femoral artery were used. Potentiation of the pressor effects of injected N A occurred in all (five artery and live kidney) preparations when jaundiced baboon plasma was perfused. These changes were significant (P ≤ 0.05) in nine out of the fen experiments. Controls to which normal baboon plasma was administered showed no such change. No correlation was found between the degree of N A potentiation and the plasma concentrations of bilirubin (total and conjugated), serum glutamic oxaloacetic transaminase, blood urea nitiogen, serum glutamic pyruvic transaminase, alkaline phosphatase, Na+ ions or K+ ions in the jaundiced plasma. Plasma renin levels were not significantly changed. When arteries were perfused with Krebs solution containing the β-lipoprotein extract of jaundiced plasma, a potentiation of NA was found. Perfusion of sodium taurocholate or sodium deoxycholale (400 μg/ml) yielded no potentiation. Thus, the altered renal perfusion associated with jaundice may be attributed to a potentiated pressor response to NA which may be caused by an increased level of cholesterol carried on the β-lipoprotein.


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