Failure of heparin to affect two types of experimental glomerulonephritis in rabbits

Border, Wayne A.; Wilson, Curtis B.; Dixon, Frank J.
September 1975
Kidney International;Sep1975, Vol. 8 Issue 3, p140
Academic Journal
Anticoagulation has been reported to ameliorate antiglomerular basement membrane glomerulonephritis (anti-GBM-GN) while its effect on chronic immune complex glomerulonephritis (IC-GN) as studied in the NZB mouse is unclear. Chronic serum sickness IC-GN was induced in rabbits by injecting bovine serum albumin (BSA) daily. Anti-GBM-GN was induced by i.v. injection of a known amount of heterologous anti-GBM antibody. Heparin was administered beginning at two to six weeks after the first BSA injections or before the administration of anti-GBM antibody, on various schedules from 5000 U every 12 hr to 8000 U every 8 hr. With this dosage the partial thromboplastin time remained greater than 1½ to 2½ times the control at the time of the subsequent heparin injection. Heparinized and nonheparinized groups were matched according to duration of disease, maximum anti-BSA concentrations or anti-GBM antibody dosage—and no significant differences were found in proteinuria; severity of the glomerular histologic lesions; or immunofluorescence patterns of immunoglobulin G (IgG), third component of complement (C3), BSA or fibrinogen-related antigen(s) (FRA). Crescent formation was not prevented. This study shows that heparin in the maximum permissible dosage is ineffective in preventing glomerular FRA deposition or altering the progression of experimental IC-GN or anti-GBM-GN in rabbits.


Related Articles

  • Spontaneous glomerular IgA deposition in ddY mice: An animal model of IgA nephritis. Imai, Hirokazu; Nakamoto, Yasushi; Asakura, Kenichi; Miki, Kazunobu; Yasuda, Tadashi; Miura, Akira B. // Kidney International;May1985, Vol. 27 Issue 5, p756 

    It was found that ddY mice derived from non-inbred dd-stock mice brought from Germany before 1920 and then raised in Japan developed spontaneously IgA dominant deposition in the glomerular mesangium. In this report we give a detailed natural history of the renal pathology of those mice. The...

  • Steroids in the Treatment of IgA Nephropathy to the Improvement of Renal Survival: A Systematic Review and Meta-Analysis. Yu-Hao Zhou; Li-Gong Tang; Shi-Lei Guo; Zhi-Chao Jin; Mei-Jing Wu; Jia-Jie Zang; Jin-Fang Xu; Chun-Fang Wu; Ying-Yi Qin; Qing Cai; Qing-Bin Gao; Shan-Shan Zhang; Dand-Hui Yu; Jia He // PLoS Clinical Trials;Apr2011, Vol. 8 Issue 4, Special section p1 

    Background: Studies have shown that steroids can improve kidney survival and decrease the risk of proteinuria in patients with Immunoglobulin A nephropathy, but the overall benefit of steroids in the treatment of Immunoglobulin A nephropathy remains controversial. The aim of this study was to...

  • Familial aggregation of primary glomerulonephritis in an Italian population isolate: Valtrompia study. Izzi, C.; Sanna-Cherchi, S.; Prati, E.; Belleri, R.; Remedio, A.; Tardanico, R.; Foramitti, M.; Guerini, S.; Viola, B. F.; Movilli, E.; Beerman, I.; Lifton, R.; Leone, L.; Gharavi, A.; Scolari, F. // Kidney International;Mar2006, Vol. 69 Issue 6, p1033 

    Hereditary factors are suspected to contribute to the pathogenesis of sporadic primary glomerulonephritis, but their contribution is difficult to delineate in the general population. We studied the prevalence of primary glomerulonephritis in an isolated population from the extreme northern...

  • Persistent microhaematuria with negative or low proteinuria. Gutiérrez, Eduardo; Moreno, Juan A.; Praga, Manuel // Nefrologia;2014, Vol. 34 Issue 1, p110 

    The level of proteinuria continues to be the clinical parameter that is best related to the development of long-term renal failure in glomerular pathologies. This quantity is particularly important when we analyse the progression of patients with IgA nephropathy. As such, the natural progression...

  • IgA nephropathy in a patient presenting with scleritis. Teixeira, Catarina; Quintas, Ana Miguel; Lopes, José António; Miranda, Margarida; de Almeida, Edgar // NDT Plus;Oct2010, Vol. 3 Issue 5, p453 

    Scleritis is a very uncommon manifestation in patients with IgA nephropathy. Here, we report the case of a patient presenting with diffuse anterior scleritis in which the laboratory disclosed microscopic haematuria and nephrotic range proteinuria. Renal function was normal. Serology for lupus,...

  • Possible involvement of terminal complement complex in active Heymann nephritis. de Heer, Emile; Daha, Mohamed R.; Bhakdi, Sucharit; Bazin, Herv&ecute;; van Es, Leendert A. // Kidney International;Feb1985, Vol. 27 Issue 2, p388 

    We investigated whether the appearance of various complement components in renal deposits of immune complexes correlated with the development of proteinuria in rats with active Heymann nephritis. Sequential kidney biopsy specimens and serum samples were obtained from Lewis rats immunized with...

  • Clinicopathologic findings relevant to disappearance or relapse of proteinuria following corticosteroid treatment in IgA nephropathy patients with proteinuria of 0.5 to 2.0?g/day. Suzuki, Takayuki; Yamamoto, Tatsuo; Ohura, Masaharu; Fujigaki, Yoshihide; Yonemura, Katsuhiko; Kimura, Masato; Hishida, Akira // Clinical & Experimental Nephrology;Sep2004, Vol. 8 Issue 3, p243 

    Background. We investigated the clinical and pathological findings relevant to the efficacy of corticosteroid treatment in IgA nephropathy patients with 0.5 to 2.0 g/day of proteinuria at the initiation of corticosteroid treatment. Methods. In 27 IgA nephropathy patients who received 2-year...

  • Myeloperoxidase-antineutrophil cytoplasmic antibody-associated crescentic glomerulonephritis in autosomal dominant polycystic kidney disease. Keiichi Sumida; Yoshifumi Ubara; Junichi Hoshino; Noriko Hayami; Tatsuya Suwabe; Rikako Hiramatsu; Eiko Hasegawa; Masayuki Yamanouchi; Naoki Sawa; Kenmei Takaichi; Kenichi Ohashi // BMC Nephrology;2013, Vol. 14 Issue 1, p1 

    Background: Autosomal dominant polycystic kidney disease (ADPKD) is an inherited disorder that is characterized by the development of cysts in the kidneys and other organs. Urinary protein excretion is usually less than 1 g/day, and ADPKD is rarely associated with nephrotic syndrome or rapidly...

  • Coexistence of ANCA-associated glomerulonephritis and anti-phospholipase A2 receptor antibody-positive membranous nephropathy. Surindran, Sheena; Ayalon, Rivka; Hasan, Nazia; Beck, Laurence H.; Salant, David J.; Barisoni, Laura; Skolnik, Edward Y.; Beara-Lasic, Lada // Clinical Kidney Journal;Apr2012, Vol. 5 Issue 2, p162 

    Antibodies to myeloperoxidase (MPO) and proteinase 3 (PR3) have been demonstrated to mediate anti-neutrophil cytoplasmic antibody (ANCA)-associated disease. For membranous nephropathy, antibodies to the podocyte-expressed phospholipase A2 receptor (anti-PLA2R) are highly associated with disease...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics