TITLE

Growth model for multicellular tumor spheroids

AUTHOR(S)
Delsanto, Pier Paolo; Guiot, Caterina; Degiorgis, Piero Giorgio; Condat, Carlos A.; Mansury, Yuri; Deisboeck, Thomas S.
PUB. DATE
November 2004
SOURCE
Applied Physics Letters;11/1/2004, Vol. 85 Issue 18, p4225
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Most organisms grow according to simple laws, which in principle can be derived from energy conservation and scaling arguments, critically dependent on the relation between the metabolic rate B of energy flow and the organism mass m. Although this relation is generally recognized to be of the form B(m)=mp, the specific value of the exponent p is the object of an ongoing debate, with many mechanisms being postulated to support different predictions. We propose that multicellular tumor spheroids provide an ideal experimental model system for testing these allometric growth theories, especially under controlled conditions of malnourishment and applied mechanical stress.
ACCESSION #
14945446

 

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