Basement membrane proteoglycans and development

Couchman, John R.; Abrahamson, Dale R.; McCarthy, Kevin J.
January 1993
Kidney International;Jan1993, Vol. 43 Issue 1, p79
Academic Journal
Basement membranes contain distinct collagen, glycoprotein and proteoglycan species, and these exhibit considerable heterogeneity in isoform or type when different tissue types are compared. Additionally. many components are differentially expressed in organogenesis. We have considered the distributions in glomerulogenesis of two distinct basement membrane proteoglycans, a small heparan sulfate proteoglycan and a chondroitin sulfate proteoglycan (BM-CSPG). While the former was present in all kidney basement membranes through development, the latter was apparently regulated in distribution. BM-CSPG was only strongly expressed in the vasculature invading late comma stage glomeruli, and later in presumptive and mature Bowman's capsule. Over the first six to eight weeks, the capillary basement membranes contained BM-CSPG, but in gradually decreasing amounts until it became completely undetectable. The basement membrane of the adult rat glomerulus is unique in its lack of BM-CSPG. However, in diabetic rats. BM-CSPG is apparently re-expressed in the glomerular basement membrane, a potential marker for pathological changes in glomerular structure. While its function awaits elucidation, BM-CSPG may be essential for basement membrane integrity or stability and have important roles in kidney development.


Related Articles

  • Regulation of glomerular basement membrane collagen expression by LMX1B contributes to renal disease in nail patella syndrome. Morello, Roy; Zhou, Guang; Dreyer, Sandra D.; Harvey, Scott J.; Ninomiya, Yoshifumi; Thorner, Paul S.; Miner, Jeffrey H.; Cole, William; Winterpacht, Andreas; Zabel, Bernhard; Oberg, Kerby C.; Lee, Brendan // Nature Genetics;Feb2001, Vol. 27 Issue 2, p205 

    Basement membrane (BM) morphogenesis is critical for normal kidney function. Heterotrimeric type IV collagen, composed of different combinations of six α-chains (1-6), is a major matrix component of all BMs (ref. 2). Unlike in other BMs, glomerular BM (GBM) contains primarily the α3(IV)...

  • Maturation of the developing renal glomerulus with respect to basement membrane proteoglycans. Lelongt, Brigitte; Makino, Hirofumi; Kanwar, Yashpal S. // Kidney International;Oct1987, Vol. 32 Issue 4, p498 

    Maturation of extracellular matrices in relation to heparan sulfate proteoglycans was investigated during glomerular development. Antibodies directed against the core-protein (Mr = 18,000) of the basement membrane heparan sulfate-proteoglycan were utilized. The IgG fraction of the antibodies was...

  • Structure and Function of Basement Membrane. Stanley, John R.; Woodley, David T.; Katz, Stephen I.; Martin, George R. // Journal of Investigative Dermatology;Jul82Supplement, Vol. 79, p69s 

    Progress has been made in identifying and characterizing basement membrane macromolecules, including type IV collagen, laminin, a heparan sulfate proteoglycan and bullous pemphigoid antigen. Basement membrane contains a unique collagen, type IV collagen, which is formed of pro α1(IV)...

  • Exclusion of eight genes as mutated loci in congenital nephrotic syndrome of the Finnish type. Kestilä, Marjo; Männikkö, Minna; Holmberg, Christer; Korpela, Kaija; Savolainen, EEva-Riita; Peltonen, Leena; Tryggvason, Karl // Kidney International;Apr1994, Vol. 45 Issue 4, p986 

    The congenital nephrotic syndrome of the Finnish type (CNF) is an autosomal recessive disease characterized by massive proteinuria already at birth. The gene locus defective in CNF was searched for using polymorphic markers of candidate genes coding for components of the basement membrane (BM)....

  • Integrins in renal development. Mathew, Sijo; Chen, Xiwu; Pozzi, Ambra; Zent, Roy // Pediatric Nephrology;Jun2012, Vol. 27 Issue 6, p891 

    The kidney develops from direct interactions between the ureteric bud and the metanephric mesenchyme. The ureteric bud gives rise to the collecting system and the metanephric mesenchyme to the nephrons. The complex process of renal development which occurs between these embryologically distinct...

  • Role of COL4A1 in Basement-Membrane Integrity and Cerebral Small-Vessel Disease. The COL4A1 Stroke Syndrome. Volonghi, I.; Pezzini, A.; Del Zotto, E.; Giossi, A.; Costa, P.; Ferrari, D.; Padovani, A. // Current Medicinal Chemistry;May2010, Vol. 17 Issue 13, p1317 

    Type IV collagens are basement membrane (BM) proteins expressed in all tissues including the vasculature. COL4A1 and COL4A2, the most abundant type IV collagens, form heterotrimers with a 2:1 stoichiometry and each heterotrimer forms a triple helix along the length of the collagenous domains....

  • Immunohistochemical Localization of Basement Membrane Components During Hair Follicle Morphogenesis. Westgate, Gillian E.; Shaw, Dennis A.; Harrap, Godfrey J.; Couchman, John R. // Journal of Investigative Dermatology;Mar1984, Vol. 82 Issue 3, p259 

    Specific antisera were used to investigate the distributions of several basement membrane zone (BMZ) components, namely, bullous pemphigoid antigen (BPA), heparan sulfate proteoglycan (HSPG), laminin, and type IV collagen, during the development of hair follicles in late embryo rats. BPA was not...

  • Nidogen mediates the formation of ternary complexes of basement membrane components. Aumailley, Monique; Battaglia, Cristina; Mayer, Ulrike; Reinhardt, Dieter; Nischt, Roswitha; Timpl, Rupert; Fox, Jay W. // Kidney International;Jan1993, Vol. 43 Issue 1, p7 

    Using a recombinant nidogen we have probed the calcium binding potential of various nidogen domains, examined the binding of nidogen to various basement membrane proteins and assessed the ability of nidogen to mediate the formation of ternary complexes between laminin and heparan sulfate...

  • COOH-terminal collagen Q ( COLQ) mutants causing human deficiency of endplate acetylcholinesterase impair the interaction of ColQ with proteins of the basal lamina. Arredondo, Juan; Lara, Marian; Ng, Fiona; Gochez, Danielle; Lee, Diana; Logia, Stephanie; Nguyen, Joanna; Maselli, Ricardo // Human Genetics;May2014, Vol. 133 Issue 5, p599 

    Collagen Q (ColQ) is a key multidomain functional protein of the neuromuscular junction (NMJ), crucial for anchoring acetylcholinesterase (AChE) to the basal lamina (BL) and accumulating AChE at the NMJ. The attachment of AChE to the BL is primarily accomplished by the binding of the ColQ...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics