Association of thin glomerular basement membrane with other glomerulopathies

Cosio, Fernando G.; Falkenhain, Michael E.; Sedmak, Daniel D.
August 1994
Kidney International;Aug1994, Vol. 46 Issue 2, p471
Academic Journal
In the present study we assessed the prevalence of thin glomerular basement membrane (TGBM) in a large group of native kidney biopsies done for evaluation of renal disease, TGBM was present in 54 of 1078 biopsies (5%). In 12 of 54 biopsies (24%), TGBM was the only abnormality present. In the remaining biopsies TGBM was associated with other pathologic diagnoses. The overall prevalence of TGBM in this series is comparable to previous population studies. TGBM is significantly more common in patients with IgA nephropathy and mesangial proliferative glomerulonephritis. Compared to control patients, individuals with TGBM were more likely to have a history of familial hematuria (14% vs. 43%, P = 0.02). Furthermore, examination of urinary sediments in first degree relatives of patients with TGBM demonstrated microscopic hematuria in 92% of families and, in those families, hematuria was present in 47 ± 6% of relatives. In contrast, hematuria was discovered in 38% of families of control patients, affecting 25 ± 5% of relatives. In conclusion, the presence of TGBM in a kidney biopsy is highly predictable for the presence of familial microscopic hematuria, even in patients in whom TGBM is associated with another glomerulopathy. The present data also indicate that patients with TGBM nephropathy often have concomitant IgA nephropathy and mesangial proliferative glomerulonephritis.


Related Articles

  • Acanthocyturia -- A characteristic marker for glomerular bleeding. Köhler, Hans; Wandel, Eveline; Brunck, Bernd // Kidney International;Jul1991, Vol. 40 Issue 1, p115 

    Erythrocyte morphology by phase contrast microscopic examination (PCM) of the urine is widely employed in distinguishing glomerular from nonglomerular bleeding. The proposed percentages of dysmorphic red cells are significant for glomerular bleeding in the range of 10 to 80% in the literature,...

  • The existence of a protracted course in crescentic glomerulonephritis. Baldwin, David S.; Neugarten, Joel; Feiner, Helen D.; Gluck, Melvin; Spinowitz, Bruce // Kidney International;Mar1987, Vol. 31 Issue 3, p790 

    We describe a spectrum of clinical and morphologic features which may occur in idiopathic crescentic glomerulonephritis. Of note are patients who pursue a more indolent course to renal failure in contrast to typical rapidly progressive glomerulonephritis (RPGN). Patients following this...

  • Incidence of biopsy-proven glomerulonephritis. Ole Wirta; Jukka Mustonen; Heikki Helin; Amos Pasternack // Nephrology Dialysis Transplantation;Jan2008, Vol. 23 Issue 1, p193 

    Background. The reported biopsy-proven glomerulonephritis incidence varies according to population characteristics, the unknown true glomerulonephritis incidence and biopsy rate. Reported glomerulonephritis incidence should be evaluated against the biopsy rate. Methods. We report here the...

  • Macrophages in childhood IgA nephropathy. Nagata, Michio; Akioka, Yuko; Tsunoda, Yuri; Komatsu, Yasuhiro; Kawaguchi, Hiroshi; Yamaguchi, Yutaka; Ito, Katumi // Kidney International;Aug1995, Vol. 48 Issue 2, p527 

    The role of glomerular macrophages in IgA nephropathy in children was investigated using a new monoclonal antibody (KP1) as a probe. The average number of glomerular macrophages per patient (ANM/P) was closely correlated with the degree of hematuria (P < 0.01) as well as with the degree of...

  • Renal biopsy in Glomerulonephritis. Rad, Masoud Pezeshki; Taghavi, Mina; Hashemi, Jahanbakhsh; Sharifipour, Farzaneh; Zeraati, Abbasali // Reviews in Clinical Medicine;2014, Vol. 1 Issue 2, p34 

    Glomerulonephritis (GN) is responsible for 25-30% of end-stage renal disease (ESRD) among all causes. Renal biopsy is important to determine the GN treatment method and its prognosis. In some cases, renal biopsy is required for definitive diagnosis. Biopsies were used as a diagnostic method in...

  • Clinicopathologic correlations of renal pathology in Spain. Rivera, Francisco; López-Gómez, Juan Manuel; Pérez-García, Rafael // Kidney International;Sep2004, Vol. 66 Issue 3, p898 

    Clinicopathologic correlations of renal pathology in Spain. Background. There are not enough large epidemiologic population-based studies of biopsy-proven nephropathies with detailed clinicopathologic correlations. Methods. The Glomerulonephritis Registry of the Spanish Society of Nephrology has...

  • Membranous Glomerulonephritis. Gluck, Melvin C.; Gallo, Gloria; Lowenstein, Jerome; Baldwin, David S. // Annals of Internal Medicine;Jan73, Vol. 78 Issue 1, p1 

    Presents information on study which examined the clinical course of membranous glomerulonephritis in patients with renal biopsies. Definition of membranous glomerulonephritis; Evolution of basement membrane lesions; Role of antigens on membranous glomerulonephritis in men.

  • Acute poststreptococcal glomerulonephritis following circumcision. Tasic, Velibor; Polenakovic, Momir // Pediatric Nephrology;Dec2000, Vol. 15 Issue 3/4, p274 

    A case of acute poststreptococcal glomerulonephritis following circumcision is presented. An 11-year-old boy was subjected to ritual circumcision, which was complicated by the infection of the wound and development of oliguria, edema, hematuria and hypertensive encephalopathy 2 weeks later. The...

  • A prospective study of the natural history of idiopathic non-proteinuric hematuria. Nieuwhof, Christina; Doorenbos, Cees; Grave, Willem; De Heer, Frans; De Leeuw, Peter; Zeppenfeldt, Ewald; Van Breda Vriesman, Peter J. C. // Kidney International;Jan1996, Vol. 49 Issue 1, p222 

    In a prospective study of idiopathic glomerulonephritis we determined the natural history of 49 adult patients (12 primary IgA nephropathy, 13 thin GBM nephropathy, 20 normal renal tissue and 4 miscellaneous nephropathies) who presented with idiopathic non-proteinuric non-azotemic hematuria of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics