TITLE

Detection of urinary interleukin-8 in glomerular diseases

AUTHOR(S)
Wada, Takashi; Yokoyama, Hitoshi; Tomosugi, Naohisa; Hisada, Yukimasa; Ohta, Satoshi; Naito, Takero; Kobayashi, Ken-ichi; Mukaida, Naofumi; Matsushima, Kouji
PUB. DATE
August 1994
SOURCE
Kidney International;Aug1994, Vol. 46 Issue 2, p455
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Detection of urinary interleukin-8 in glomerular diseases. To clarify the mechanism of neutrophil infiltration in glomerulonephritis, both urinary and plasma levels of a potent neutrophil chemotactic cytokine, interleukin-8 (IL-8), were measured in 40 healthy volunteers and 96 patients with various renal diseases. The plasma IL-8 levels were less than 16 pg/ml. The urinary IL-8 levels were elevated in several renal diseases including IgA nephropathy (17 of 43), acute glomerulonephritis (4 of 6), lupus nephritis (11 of 15), purpura nephritis (2 of 4), membranoproliferative glomerulonephritis (1 of 1), and cryoglobulinemia (2 of 2), IL-8 was detected immunohistochemically in diseased glomeruli, suggesting its local production. Elevated urinary IL-8 levels during the acute phase or exacerbations were found to be decreased during spontaneous or steroid pulse therapy-induced convalescence in all patients examines. The urinary IL-8 levels were higher in patients with glomerular leukocyte infiltration than in those without infiltration. Collectively, local production of IL-8 in diseased glomeruli might be involved in the pathogenesis of the glomerular diseases and measurement of IL-8 in the urine might be useful for monitoring the glomerular diseases.
ACCESSION #
14889339

 

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