LUNG ALERT: Mechanisms of tolerance and Th2 cell activation in asthma

Baghai-Ravary, R.
October 2004
Thorax;Oct2004, Vol. 59 Issue 10, p909
Academic Journal
This article discusses mechanisms of tolerance and T helper 2 cell activation in asthma. ultiple factors are involved in the correct regulation of an immune response to common antigens. Two studies using asthma models in mice provide an insight into the immunological mechanisms of T helper 2 (Th2) cell activation in atopic asthma. There are two subsets of human and mouse dentritic cells (DC): the myeloid and plasmacytoid (pDC) types. Atopic asthma may be caused by pDC dysfunction, but this hypothesis remains to be proven before treatments aimed at potentiating pDC activity can be considered. The authors suggest that early antigen exposure could induce tolerance to commonly inhaled antigens in those at risk of allergic disease.


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