LUNG ALERT: Sensitivity of pulmonary function test in whether bronchodilatation is different in healthy subject and asthmatics

Menon, M.
October 2004
Thorax;Oct2004, Vol. 59 Issue 10, p875
Academic Journal
This article presents information on sensitivity of pulmonary function tests in assessing whether bronchodilatation is different in healthy subjects and asthmatics. The ability of different pulmonary function tests to detect dose-response effects depends on both the variability and sensitivity of the methods used. In clinical trials bronchodilatation is usually assessed by spirometry. Researchers compared the sensitivity and variability of the above pulmonary function methods to measure the dose-response effects of salbutamol in both healthy subjects and asthmatics. The study involved 12 healthy subjects, 12 with mild asthma and 12 with moderate asthma. The most sensitive measurements were spirometry in healthy individuals and plethysmography in those with mild asthma.


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